Integrating transdisciplinary approaches to learning outcomes via emerging technologies in line with SDGs is the current concern in many ASEAN countries and beyond. This Chapter reports studies by co-authors who led technology-enhanced programmes related to science and social science studies from Thailand, Malaysia, Singapore, Indonesia, China and India. Qualitative case study as research design was implemented involving mixed-mode of data collection and analysis. Literature review is made on pertinent terminologies e.g. transdisciplinarity, open and distant learning (ODL) also emerging technologies, local wisdom/culture, etc. Cross-Case Analysis (CCA) was conducted to outline the common features of selected technology-enhanced programmes organised involving emerging technologies. Exemplary-Case Analysis (ECA) is also elaborated focusing on selected programmes supporting SDGs. Promoting transdisciplinary studies leads to implications worth deliberated and recommendations are made for future studies.