Design and development of novel formulation of Aloe Vera nanoemulsion gel contained erythromycin for topical antibacterial therapy: In vitro and in vivo assessment

Valizadeh, Alireza; Darvishi, Mohammad Hasan; Amani, Amir; Zarchi, Ali Akbar Karimi

doi:10.1016/j.jddst.2022.103519

Cited by 10 publications

(4 citation statements)

References 53 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The release rate is governed by the concentra- The versatile nature of AV gel has significant potential in the field of pharmaceutical applications, particularly in improving the absorption capabilities of poorly absorbed orally administered drugs. Different formulations can encapsulate poorly absorbed drugs, while AV gel acts as a stabilizing and enhancing agent [119][120][121]. Due to its outstanding efficacy and compatibility with different drug carriers, the use of AV can be further expanded in potential applications and provides a flexible platform for optimizing oral drug delivery.…”

Section: Biological and Pharmacological Effects Of Aloe Veramentioning

confidence: 99%

Aloe vera-Based Hydrogels for Wound Healing: Properties and Therapeutic Effects

Chelu

Musuc

Popa

et al. 2023

Gels

View full text Add to dashboard Cite

Aloe vera-based hydrogels have emerged as promising platforms for the delivery of therapeutic agents in wound dressings due to their biocompatibility and unique wound-healing properties. The present study provides a comprehensive overview of recent advances in the application of Aloe vera-based hydrogels for wound healing. The synthesis methods, structural characteristics, and properties of Aloe vera-based hydrogels are discussed. Mechanisms of therapeutic agents released from Aloe vera-based hydrogels, including diffusion, swelling, and degradation, are also analyzed. In addition, the therapeutic effects of Aloe vera-based hydrogels on wound healing, as well as the reduction of inflammation, antimicrobial activity, and tissue regeneration, are highlighted. The incorporation of various therapeutic agents, such as antimicrobial and anti-inflammatory ones, into Aloe vera-based hydrogels is reviewed in detail. Furthermore, challenges and future prospects of Aloe vera-based hydrogels for wound dressing applications are considered. This review provides valuable information on the current status of Aloe vera-based hydrogels for the delivery of therapeutic agents in wound dressings and highlights their potential to improve wound healing outcomes.

show abstract

Section: Biological and Pharmacological Effects Of Aloe Veramentioning

confidence: 99%

Aloe vera-Based Hydrogels for Wound Healing: Properties and Therapeutic Effects

Chelu

Musuc

Popa

et al. 2023

Gels

View full text Add to dashboard Cite

show abstract

“…Formulasi hand sanitizer berbahan dasar bahan alam sejauh ini dianggap aman bagi kesehatan manusia dan lingkungan [7] dan [8]. Beberapa bahan alam yang mempunyai kemampuan antiseptik antara lain sirih hijau [9], [10], [11], [12], [13], [14], [15], dan [16], bawang putih [17], sereh [18], kayu manis [19] dan [20], rosemary [21], oregano [22], lidah buaya [18], [23], dan [24], dan teh hijau [25]. Dibandingkan dengan beberapa bahan alam seperti tersebut di atas, selain mempunyai daya antiseptik yang sangat baik, daun sirih hijau juga mudah diperoleh dengan harga yang murah.…”

Section: Pendahuluanunclassified

An Investigation into the Effectiveness of Green Betel (Piper betle L.) Leaf Extract Hand Sanitizer

2023

View full text Add to dashboard Cite

Green betel (Piper betle L.) leaf contains anti-thrush, anti-cough, astringent, and antiseptic chemicals such as saponins, flavonoids, polyphenols, and essential oils. Hand sanitizer can also be used as an antiseptic agent, which is a more practical option. The purpose of this study was to see how the composition of green betel leaf extract made by infusion affected its physical properties and bacterial inhibition. Hand sanitizer samples were made using different concentrations of green betel leaf extract (10 - 25 wt%) with and without the addition of tea tree essential oil. Sample testing included organoleptic tests, physical properties tests, and effectiveness tests on the growth of Escherichia coli bacteria. The results showed that the best composition was found to be at a concentration of 10 wt% green betel leaf extract without the addition of essential oil, with pH ranging from 5.2 to 5.8 and viscosities ranging from 1.32 to 1.99 cps, in the form of a watery gel and a clear yellow color. Meanwhile, hand sanitizer sensitivity testing revealed that none of the samples could inhibit the growth of Escherichia coli bacteria. This indicates that the concentration of green betel leaf extract in the sample is still insufficient to inhibit bacterial growth.

show abstract

“…Murugesan et al demonstrated, in turn, that Aloe vera gel contains compounds showing anticancer activity [14]. In other publications, it was also demonstrated that nanoemulsion gels that are based on Aloe vera demonstrated antibacterial properties towards both gram-negative and gram-positive bacteria, anti-inflammatory properties, and importantly, they stimulated the synthesis of collagen [15].…”

Section: Introductionmentioning

confidence: 96%

Verification of the Influence of the 2-Hydroxy-2-methylpropiophenone (Photoinitiator) Content in Hydrogel Materials on Their Physicochemical Properties and Surface Morphology

et al. 2022

View full text Add to dashboard Cite

Currently, hydrogel materials are being widely developed and investigated. Factors affecting their properties may be mentioned, such as the types and the amounts of the reagents used for the synthesis of the hydrogel matrix and modifiers; thus, the main aim of the investigations was to check the impact of the amount of photoinitiator applied during the UV-induced polymerization of polyvinylpyrrolidone-based hydrogels incorporated with vitamin C and Aloe vera juice. The experiments that were performed were focused on determining the hydrogels’ swelling capability, behavior in simulated body fluids, hydrophilicity, chemical structure (using FT-IR spectroscopy), as well as their surface morphology and roughness. It was proven that developed materials had relatively rough surfaces, they did not degrade in simulated physiological liquids, and their swelling ratios in these media were 2.0–3.0 g/g. The only change in the pH of the incubation media—a slight decrease—was caused by the release of the modifiers into the tested liquids. Subsequently, it was demonstrated that as the amount of the photoinitiator (2-hydroxy-2-methylpropiophenone) increased, the percentage elongation decreased, and the tensile strength increased. The content of the photoinitiator in the hydrogels also influenced their wettability. All samples showed hydrophilicity; the more photoinitiator in the hydrogel structure, the lower wetting angle for water. Moreover, the greater the amount of 2-hydroxy-2-methylpropiophenone, the smoother and more homogeneous the hydrogel surface; thus, considering the demonstrated physicochemical properties of developed materials, they seem to show application potential for more advanced research regarding the development of innovative dressing materials.

show abstract

Design and development of novel formulation of Aloe Vera nanoemulsion gel contained erythromycin for topical antibacterial therapy: In vitro and in vivo assessment

Cited by 10 publications

References 53 publications

Aloe vera-Based Hydrogels for Wound Healing: Properties and Therapeutic Effects

Aloe vera-Based Hydrogels for Wound Healing: Properties and Therapeutic Effects

An Investigation into the Effectiveness of Green Betel (Piper betle L.) Leaf Extract Hand Sanitizer

Verification of the Influence of the 2-Hydroxy-2-methylpropiophenone (Photoinitiator) Content in Hydrogel Materials on Their Physicochemical Properties and Surface Morphology

Contact Info

Product

Resources

About