Design and development of novel fasudil derivatives as potent antibreast cancer agent that improves intestinal flora and intestinal barrier function in rats

Liang, Jinghui; Tang, Mu; Wang, Lieliang; Huang, Rui; Fu, Ailong; Zhou, Juying

doi:10.1111/cbdd.13963

Cited by 5 publications

(4 citation statements)

References 38 publications

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“…Intestinibacter, a genus of gut bacteria that is not yet widely understood, and its association with renal malignant tumors has also been the subject of recent research. There is a positive causal effect between the relative abundance of Intestinibacter in the intestinal ora and the development of renal malignant tumors, i.e., individuals with a relatively higher abundance of Intestinibacter are more likely to develop renal malignant tumors 57 . Intestinibacter may be associated with the development of renal malignancies through pathways such as metabolites, activation of immune responses, or in uence on cell signaling pathways 58 .…”

Section: Discussionmentioning

confidence: 99%

Association study between intestinal flora and renal malignancy based on genome-wide association analysis data

Gan,

Yuan,

Wang

et al. 2023

Preprint

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Objective Gut microbiome (GM) plays an important role in a variety of diseases, and renal malignancies have been shown to be closely associated with GM. However, the role of GM in the pathogenesis of renal malignancies has not been fully explored. The aim of this study was to investigate the potential causal association between intestinal flora and renal malignancies and the possible mechanisms of action. Methods We collected genome-wide association study (GWAS) data on GM and renal malignancies and applied Mendelian randomization (MR) analysis to explore the causal association between them. Results By MR analysis, we found that GM components associated with renal malignancies, including enterobacteria of certain orders, families, and genera, may have negative causal effects in the pathogenesis, while enterobacteria of other orders, families, and genera may have positive causal associations with renal malignancies. Conclusion This study reveals a possible causal association between intestinal flora and renal malignancies and identifies several genetic variants involved in this association. These findings are expected to provide new insights into the pathogenesis of renal malignancies and provide a theoretical basis for the development of therapeutic strategies targeting intestinal flora in the future.

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Section: Discussionmentioning

confidence: 99%

Association study between intestinal flora and renal malignancy based on genome-wide association analysis data

Gan,

Yuan,

Wang

et al. 2023

Preprint

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“…Compound 31 was also active in a scratch assay performed on human breast cancer MDA‐MB 231 cells, 87 By introducing the pyridine‐thiozole group into Fasudil, Liang observed that compound 32 showed potent inhibition of ROCK. The most potent compound 32a could significantly inhibit the viability of breast cancer cells (MCF‐7) and improve intestinal flora and intestinal barrier function in rats 88 . Domokos et al reported that 1‐substituted tetrahydroisoquinoline (compound 33 ) and its ring‐opening analog (compound 34 ) exhibited ROCK II inhibitory activity similar to Y‐27632, and relaxed the 20‐day pregnant and parturient rat uterus with greater potency as compared to Fasudil 89 .…”

Section: Synthetic Rock Inhibitorsmentioning

confidence: 99%

“…The most potent compound 32a could significantly inhibit the viability of breast cancer cells (MCF-7) and improve intestinal flora and intestinal barrier function in rats. 88 Fasudil. 89 Utilizing modern computer-aided drug design techniques, Kesar et al found that quinoline compound 35 exhibited potent ROCK II inhibition with an IC 50 value of 8.02 nM.…”

Section: Isoquinolines and Quinolinesmentioning

confidence: 99%

Recent advances in the development of Rho kinase inhibitors (2015–2021)

Yao

2023

Medicinal Research Reviews

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Rho‐associated coiled‐coil kinases (ROCKs) are key downstream effectors of small GTPases. ROCK plays a central role in diverse cellular events with accumulating evidence supporting the concept that ROCK is important in tumor development and progression. Numerous ROCK inhibitors have been investigated for their therapeutic potential in the treatment of cancers. In this article, we review recent research progress on ROCK inhibitors, especially those with potential for the treatment of cancers, reported in the literature from 2015 to 2021. Most ROCK inhibitors show potent in vitro and in vivo antitumor activities and have potential in the treatment of cancers.

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“…Shang et al [ 159 ] reported that chondroitin sulfate (SCS) in sturgeon might inhibit the growth of CRC by regulating the gut microbiota and altering the manufacture of certain amino acids. Liang et al [ 160 ] demonstrated the development of a novel fasudil derivative, which can improve the gut microbiota and the function of the intestinal barrier in rats, and may act as a potent anti-breast cancer (BC) drug. Emerging studies have indicated that next-generation probiotics (NGPs) have beneficial effects in preventing carcinogenesis and provide new promising therapeutic options for cancer patients.…”

Section: Radiotherapy For Cancer Based On the Gut Microbiotamentioning

confidence: 99%

New Insights into the Relationship between Gut Microbiota and Radiotherapy for Cancer

Zuo

et al. 2022

Nutrients

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Cancer is the second most common cause of death among humans in the world, and the threat that it presents to human health is becoming more and more serious. The mechanisms of cancer development have not yet been fully elucidated, and new therapies are changing with each passing day. Evidence from the literature has validated the finding that the composition and modification of gut microbiota play an important role in the development of many different types of cancer. The results also demonstrate that there is a bidirectional interaction between the gut microbiota and radiotherapy treatments for cancer. In a nutshell, the modifications of the gut microbiota caused by radiotherapy have an effect on tumor radiosensitivity and, as a result, affect the efficacy of radiotherapy and show a certain radiation toxicity, which leads to numerous side effects. What is of new research significance is that the “gut-organ axis” formed by the gut microbiota may be one of the most interesting potential mechanisms, although the relevant research is still very limited. In this review, we combine new insights into the relationship between the gut microbiota, cancer, and radiotherapy. Based on our current comprehensive understanding of this relationship, we give an overview of the new cancer treatments based on the gut microbiota.

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Design and development of novel fasudil derivatives as potent antibreast cancer agent that improves intestinal flora and intestinal barrier function in rats

Cited by 5 publications

References 38 publications

Association study between intestinal flora and renal malignancy based on genome-wide association analysis data

Association study between intestinal flora and renal malignancy based on genome-wide association analysis data

Recent advances in the development of Rho kinase inhibitors (2015–2021)

New Insights into the Relationship between Gut Microbiota and Radiotherapy for Cancer

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