Design and Development of Tantalum and Strontium Ion Doped Hydroxyapatite Composite Coating on Titanium Substrate: Structural and Human Osteoblast-like Cell Viability Studies

Abstract

In order to reduce the loosening of dental implants, surface modification with hydroxyapatite (HA) coating has shown promising results. Therefore, in this present study, the sol-gel technique has been employed to form a tantalum and strontium ion-doped hybrid HA layer coating onto the titanium (Ti)-alloy substrate. In this study, the surface modification was completed by using 3% tantalum pent oxide (Ta2O5), 3% strontium (Sr), and a combination of 1.5% Ta2O5 and 1.5% Sr as additives, along with HA gel by spin coating technique. These additives played a prominent role in producing a porous structure layer coating and further cell growth. The MG63 cell culture assay results indicated that due to the incorporation of strontium ions along with tantalum embedded in HA, cell proliferation increased significantly after a 48 h study. Therefore, the present results, including microstructure, crystal structure, binding energy, and cell proliferation, showed that the additives 1.5% Ta2O5 and 1.5% Sr embedded in HA on the Ti–substrate had an optimized porous coating structure, which will enhance bone in-growth in surface-modified Ti-implants. This material had a proper porous morphology with a roughness profile, which may be suitable for tissue in-growth between a surface-modified textured implant and bone interface and could be applicable for dental implants.

Recent Advance of Strontium Functionalized in Biomaterials for Bone Regeneration

“…Therefore, an ideal bone graft material should promote osteogenesis and replace bone defects at the same time. Since metal elements play an important role in promoting bone healing in the process of bone regeneration, such as strontium (Sr), iron (Fe), magnesium (Mg), calcium (Ca), and tantalum (Ta), researchers have started to explore the application of metal elements in combination with bone graft materials in order to improve the bone regeneration and repair ability of conventional bone graft materials [ 4 , 5 , 6 , 7 ]. Compared with other ions, Sr has attracted the attention of researchers because of its dual regulatory ability to promote osteoblast proliferation and inhibit osteoclast activity [ 8 , 9 ].…”

Expounded Photoelectric and Electrochemical Profiling of LRE3+:β‐Ta2O5 (Ln3+ = Ce3+, Pr3+, Nd3+) for High Performance in Energy Systems

“…Particularly, the bands located on 602 and 581 cm −1 for precursor and thin films indicated the presence of metal oxides, i.e., O ≡ 3Ta or Ta–O–Ta. [ 26 ] In addition to these specific bands, other bands appearing between 700 and 1,000 are also attributable to O ≡ 3Ta and Ta–O–Ta bonds, as indicated by the other relevant investigation done on Ta 2 O 5 . [ 27 ] In addition to the confirmation of Ta bonds, transmission bands in this region are also indicative of the lanthanide oxide bonds.…”

Nano-Topographically Guided, Biomineralized, 3D-Printed Polycaprolactone Scaffolds with Urine-Derived Stem Cells for Promoting Bone Regeneration

“…Ideal biomineralized coating on the surface of scaffolds can mimic the microenvironment of natural bone tissue, provide appropriate biochemical and physical signals, guide the osteogenic differentiation of stem cells, and enhance the deposition and mineralization of bone matrix after implantation [ 50 ]. Alkaline phosphatase (ALP) is highly expressed in the cells of mineralized tissue and plays an important role in hard tissue formation.…”