2015
DOI: 10.1016/j.colsurfb.2015.10.026
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Design and elaboration of freeze-dried PLGA nanoparticles for the transcorneal permeation of carprofen: Ocular anti-inflammatory applications

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Cited by 41 publications
(35 citation statements)
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“…The backscattering profile for MEM‐NPs maintained at 25 °C for 24 h is shown in Figure . Except for peripheral peaks at the vial edges, a constant signal around 38% could be observed throughout the study without variations higher than 10% thus indicating good short‐term stability of the formulation . In vitro release of memantine fit well ( R 2 = 0.976) to a single phase exponential association equation (Equation liberating all memantine within 4 h with a half‐life of 0.74 h ( Figure ).…”
Section: Resultsmentioning
confidence: 77%
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“…The backscattering profile for MEM‐NPs maintained at 25 °C for 24 h is shown in Figure . Except for peripheral peaks at the vial edges, a constant signal around 38% could be observed throughout the study without variations higher than 10% thus indicating good short‐term stability of the formulation . In vitro release of memantine fit well ( R 2 = 0.976) to a single phase exponential association equation (Equation liberating all memantine within 4 h with a half‐life of 0.74 h ( Figure ).…”
Section: Resultsmentioning
confidence: 77%
“…Except for peripheral peaks at the vial edges, a constant signal around 38% could be observed throughout the study without variations higher than 10% thus indicating good short-term stability of the formulation. [28] In vitro release of memantine fit well (R 2 = 0.976) to a single phase exponential association equation (Equation 1) liberating all memantine within 4 h with a half-life of 0.74 h (Figure 5). To assess the proportion of memantine that had been incorporated into the aqueous interior of the double emulsion compared to the surrounding hydrophobic (oil phase) milieu in vitro release from MEM-NPs was fit to a one-phase (Equation 1) or two-phase exponential association equation (Equations 1 and 2, respectively [29] ) constraining the fast half-life as that for free memantine…”
Section: Plga-peg Nanocarriers Encapsulate Memantine and Demonstrate mentioning
confidence: 73%
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“…Ocular tissues were kept moist by placing them in Hank's balanced salt solution in order to maintain the viability of the cells. 26 The excised tissue (cornea or sclera) was fixed between clamped donor and receptor compartments of the perfusion with a diffusion area of 0.64 cm 2 . In all, 200 µL of the test formulation was applied to the tissue surface in the donor compartment, and the receptor compartment of the cell was filled with 6 mL of PBS.…”
Section: In Vitro Releasementioning
confidence: 99%