Design and evaluation of an adaptive multipinhole collimator for high-performance clinical and preclinical imaging

Abstract

The new collimator yields substantial improvement in image quality as compared with current MPI using LEHR with extra capability for SAI, bridging the clinical and preclinical imaging based on the same platform.

Review on Recent Developments in Collimators of Single Photon Emission Computed Tomography Imaging

“…Multi pin-hole collimators have focused peripheral apertures to the FOV [43,44]. SPECT imaging with pin-hole includes small organs such as thyroid, parathyroid glands, knee joints, breast, and also small animal's physiological imaging [7,14,[45][46][47].…”

“…In comparison with a parallel-hole collimator, a pinhole collimator has a smaller Field of View (FOV) and so preferred in focal uptake imaging [7,20]. Due to the small FOV, pin-hole collimation has insufficient axially coverage of an entire animal for small animal imaging and also suffers from the low detection efficiency [13,14,45]. A multi-pin-hole collimator allows increasing FOV, sensitivity and detection efficiency without reducing the spatial resolution [13,14,45].…”

“…Due to the small FOV, pin-hole collimation has insufficient axially coverage of an entire animal for small animal imaging and also suffers from the low detection efficiency [13,14,45]. A multi-pin-hole collimator allows increasing FOV, sensitivity and detection efficiency without reducing the spatial resolution [13,14,45]. for imaging high energy gamma rays [50] In addition to pin-holes, which were used as SPECT collimators, the Clustered Multi-Pin-hole (CMP) collimation provides simultaneous sub-millimeter imaging in SPECT and PET, either due to the narrower opening angles (Figure 4), penetration of the photons decreases through the pin-hole edges [50].…”

“…for imaging high energy gamma rays [50] In addition to pin-holes, which were used as SPECT collimators, the Clustered Multi-Pin-hole (CMP) collimation provides simultaneous sub-millimeter imaging in SPECT and PET, either due to the narrower opening angles (Figure 4), penetration of the photons decreases through the pin-hole edges [50]. However, overlap of the projections through the pin-holes is a primary limitation in a multi-pin-hole collimation, but detector coverage of the collimator is rather efficient by several projections through the multi-pin-holes [13,14,45]. The slit-slat collimation combines parallel hole and pin-hole properties and allows a better detection efficiency than a multi-pin-hole collimator [51][52][53][54].…”

Integration of the function generation synthesis into the design of a multi-leaf collimator

“…In their study collimator parameters were optimized for different sized lesions located in various depths. Si et al [3] studied on the design and optimization of a multipinhole collimator for improved medical imaging. During their study, utilizing Monte Carlo and analytical simulations, authors introduced valuable improvements on an optimized collimator design in terms of imaging resolution and detection efficiency.…”