Design and evaluation of an innovative floating and bioadhesive multiparticulate drug delivery system based on hollow structure

Controlled-release nanoencapsulating microcapsules to combat inflammatory diseases

“…For example, floating lipid beads showed better oral bioavailability (162.7%) of Cinnarizine as compared to non-floatable Stugeron ® 34. In addition, Ofloxacin-loaded floating hollow microcapsules exhibited a higher oral bioavailability (124.1%) as compared to commercial Ofloxacin tablets 35. The buoyancy of the PLGA microcapsules and PLGA/PCL microcapsules is plotted in Figure 5.…”

Premium ethylcellulose polymer based architectures at work in drug delivery

“…with the exception of drug carriers characterized by larger surface areas such as pellets and granules in which cases, the release kinetics tend to be significantly more rapid. Besides, drug release from formulations such as ethylcellulose coated microcapsules may also be a function of the capsular wall thickness in addition to the surface area (Grund et al, 2014, Muschert et al, 2009, Rowe et al, 2009, Zhang et al, 2016a, Zhang et al, 2016b).…”

“…As an ofloxacin-loaded floating bioadhesive multiparticulate delivery system (Fig. 5(a)), ethylcellulose in the form of Surelease® E-7-19040 combined with Eudragit® NE 30D were used to achieve optimal weight gain for robust pellet core structures and as coating which aided an extended release characteristic (Zhang et al, 2016a, Zhang et al, 2016b). Muschert et al (2009) developed multi-layered pellet delivery systems (Fig.…”

“…Ethylcellulose aqueous dispersion NF (Aquacoat®) was employed as an external coat layer and it was discovered that amongst other applied excipients layers, it was dominant for exhibited sustained release characteristics, minimized potential effects of pellet core type and nature of the surrounding bulk fluid.

Fig. 5(a) Morphological differences exhibited by Ethocel™ based (a) ofloxacin-loaded floating bioadhesive multiparticulate delivery system (adapted from Zhang et al, 2016a, Zhang et al, 2016b), (b) multi-layered pellets (adapted from Muschert et al, 2009), (c) tacrolimus containing extended release granules (adapted from Tsunashima et al, 2016), (d) rough surfaced pellets (adapted from Priese et al, 2015), (e) osmotic theophylline pellets (adapted from Kazlauske et al, 2017), (f) reservoir type extended release multiparticulates (adapted from Franc et al, 2016), (g) wax based floating sustained-release dispersion pellets (adapted from Yan et al, 2016).

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Aplicação de resina poliuretânica derivada do óleo de mamona em formas farmacêuticas gastrorretentivas de liberação controlada

“…were the most used as coating. There are few non-effervescent pellets described in the literature, they can be obtained by producing hollow cores due to solubilisation of a water soluble excipients, such as sugar (NANDE, 2009;ZHANG et al, 2016) and mannitol (LI et al, 2014), by producing a porous matrix due to sublimation of a volatile substance (HWANG et al, 2016) or through CO2 release from the NaHCO3 thermal degradation (VO et al, 2017).…”