Design and evaluation of switchable-hydrophilicity solvents

Abstract

Switchable-hydrophilicity solvents (SHS) can switch reversibly between one form that is miscible with water and another that forms a biphasic mixture with water. New examples are reported and compared in terms of safety and environmental impact.

Tools and techniques for solvent selection: green solvent selection guides

“…To do this more data will be required, especially for new solvents regarding their physical properties and their environmental impact. The role of the general purpose solvent selection guide is now only to expand its coverage to neoteric solvents so that they may be judged on a par with conventional solvents, and consequently stimulate research into the design of new solvents [97].…”

Tunable solvents: Shades of green

“…Switchable hydrophilicity solvents can be thought of as a related type of solvent capable of large changes in polarity [45][46][47]. This can be shown on a solvent polarity map by plotting the solvatochromic Kamlet-Abboud-Taft scales of dipolarity and hydrogen bond accepting ability (Fig.…”

A fully automated effervescence-assisted switchable solvent-based liquid phase microextraction procedure: Liquid chromatographic determination of ofloxacin in human urine samples

“…The second is based on the use of so-called switchable hydrophilicity solvents (SHS) for microextraction [15,16]. These solvents (usually amidines and secondary/tertiary amines) can be switched between hydrophobic and hydrophilic forms, depending on the solution composition [17]. Both procedures were further developed also by other authors [18e20].…”