Design and evaluation of the MAMMI dedicated breast PET

Moliner, L.; González, Antonio J.; Soriano, Antonio; Sánchez, F.; Correcher, Carlos; Orero, A.; Carles, M.; Vidal, Luis; Barberá, Julio; Caballero, L.; Seimetz, M.; Vázquez, Claudio; Benlloch, J.

doi:10.1118/1.4742850

Cited by 107 publications

(100 citation statements)

References 67 publications

(72 reference statements)

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“…Because of small sample sizes in subgroups, width of bootstrap 95% confidence interval for each bar ranges from 22% to 48% (median, 37%) for IDC, 15% to 70% (median, 33%) for ILC, and 36% to 76% (median, 47%) for DCIS. scanners whose detectors completely surround the breast (4,11,12) or that rotate to obtain complete 360°angular sampling (6,7) are capable of fully 3-dimensional, isotropic tomographic images. The impact of the anisotropic resolution on our results, and potential benefits of isotropic resolution for lesion detection, are not clear.…”

Section: Discussionmentioning

confidence: 99%

“…Mot ivated by remaining challenges in diagnosis, staging, and management of breast cancer, small, high-resolution PET scanners dedicated to breast imaging have been investigated since the 1990s (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13). Dedicated breast PET systems (positron emission mammography [PEM]) have spatial resolutions better than whole-body (WB) PET scanners by factors of 2-4 and are much smaller than WB PET scanners, allowing placement of the detectors close to the breast, thus increasing geometric detection efficiency for annihilation photons relative to WB PET.…”

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confidence: 99%

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Positron Emission Mammography Image Interpretation for Reduced Image Count Levels

et al. 2015

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We studied the effects of reduced 18 F-FDG injection activity on interpretation of positron emission mammography (PEM) images and compared image interpretation between 2 postinjection imaging times. Methods: We performed a receiver-operating-characteristic (ROC) study using PEM images reconstructed with different count levels expected from injected activities between 23 and 185 MBq. Thirty patients received 2 PEM scans at postinjection times of 60 and 120 min. Half of the patients were scanned with a standard protocol; the others received one-half of the standard activity. Images were reconstructed using 100%, 50%, and 25% of the total counts acquired. Eight radiologists used a 5-point confidence scale to score 232 PEM images for the presence of up to 3 malignant lesions. Paired images were analyzed with conditional logistic regression and ROC analysis to investigate changes in interpretation.Results: There was a trend for increasing lesion detection sensitivity with increased image counts: odds ratios were 2.2 (P 5 0.01) and 1.9 (P 5 0.04) per doubling of image counts for 60-and 120-min uptake images, respectively, without significant difference between time points (P 5 0.7). The area under the ROC curve (AUC) was highest for the 100%-count, 60-min images (0.83 vs. 0.75 for 50%-counts, P 5 0.02). The 120-min images had a similar trend but did not reach statistical significance (AUC 5 0.79 vs. 0.73, P 5 0.1). Our data did not yield significant trends between specificity and image counts. Lesion-to-background ratios increased between 60-and 120-min scans (P , 0.001). Conclusion: Reducing the image counts relative to the standard protocol decreased diagnostic accuracy. The increase in lesion-to-background ratio between 60-and 120-min uptake times was not enough to improve detection sensitivity in this study, perhaps in part due to fewer counts in the later scan. Mot ivated by remaining challenges in diagnosis, staging, and management of breast cancer, small, high-resolution PET scanners dedicated to breast imaging have been investigated since the 1990s (1-13). Dedicated breast PET systems (positron emission mammography [PEM]) have spatial resolutions better than whole-body (WB) PET scanners by factors of 2-4 and are much smaller than WB PET scanners, allowing placement of the detectors close to the breast, thus increasing geometric detection efficiency for annihilation photons relative to WB PET. In theory, increased detector efficiency allows for lower injected activities or shorter scan times while maintaining a fixed image noise level.Increased detector efficiency adds to the number of detected coincidence counts during a scan, which is the underlying metric determining inherent image noise. The activity injected into the patient (A inj ), uptake time (T up ), scan duration (T s ), and detector efficiency are the primary factors determining the number of PEM scan counts. The PEM Flex Solo II scanner (PEM Flex; CMR Naviscan) consists of 2 bar detectors (6 · 16 cm imaging area) that scan in unison along the 6-cm ...

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Section: Discussionmentioning

confidence: 99%

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confidence: 99%

Positron Emission Mammography Image Interpretation for Reduced Image Count Levels

et al. 2015

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“…The time resolution achieved with the TDC and the PET system could reduce the coincidence window to a value of between 1.5 and 2 ns (in this prototype the coincidence window was set to 5 ns in most of the experiments [9,10]). This will decrease the number of acquired random events, which for a breast dedicated PET might be significant.…”

Section: Summary and Discussionmentioning

confidence: 99%

“…MAMMI is a dedicated breast PET suitable for the detection of small size tumor lesions as well as for cancer therapy assessment [9] [10]. MAMMI consists of 12 identical detector modules with a scanner aperture of 186 mm.…”

Section: Mammi Breast Pet Prototypementioning

confidence: 99%

Time of flight measurements based on FPGA using a breast dedicated PET

Aguilar¹,

Garcia-Olcina²,

Martos³

et al. 2014

J. Inst.

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IOP PublishingAguilar, A.; García Olcina, R.; Martos, J.; Soret, J.; Torres-Pais, J.; Benlloch Baviera, JM.; González Martínez, AJ.... (2014) ABSTRACT: In this work the implementation of a Time-to-Digital Converter (TDC) using a Nutt delay line FPGA-based and applied on a Positron Emission Tomography (PET) device is going to be presented in order to check the system's suitability for Time of Flight (TOF) measurements. In recent years, FPGAs have shown great advantages for precise time measurements in PET. The architecture employed for these measurements is described in detail. The system developed was tested on a dedicated breast PET prototype, composed of LYSO crystals and Positive Sensitive Photomultipliers (PSPMTs). Two distinct experiments were carried out for this purpose. In the first test, system linearity was evaluated in order to calibrate the time measurements, providing a linearity error of less than 2% and an average time resolution of 1.4 ns FWHM. The second set of measurements tested system resolution, resulting in a FWHM as good as 1.35 ns. The results suggest that the coincidence window for the current PET can be reduced in order to minimize the random events and thus, achieve better image quality.

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“…Sensitivity, image reconstruction, and cost are taken into account when choosing PEM geometry. There are several different geometric designs such as rectangular geometry (four detector plates surrounding the breast [12]), ring geometry [13], and coplanar geometry [11]. The coplanar detector geometry based on scintillation crystals is the most used, since it provides great spatial resolution in plane 1 down to 2 mm full width at half maximum (FWHM) [11] and high contrast images with 4 mm minimum detectable lesion size for 10:1 tumor to normal tissue ratio [14].…”

Section: Introductionmentioning

confidence: 99%

Modeling and simulation of Positron Emission Mammography (PEM) based on double-sided CdTe strip detectors

Ozsahin¹,

Unlu²

2014

J. Inst.

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Breast cancer is the most common leading cause of cancer death among women. Positron Emission Tomography (PET) Mammography, also known as Positron Emission Mammography (PEM), is a method for imaging primary breast cancer. Over the past few years, PEMs based on scintillation crystals dramatically increased their importance in diagnosis and treatment of early stage breast cancer. However, these detectors have significant limitations like poor energy resolution resulting with false-negative result (missed cancer), and false-positive result which leads to suspecting cancer and suggests an unnecessary biopsy.In this work, a PEM scanner based on CdTe strip detectors is simulated via the Monte Carlo method and evaluated in terms of its spatial resolution, sensitivity, and image quality. The spatial resolution is found to be ∼ 1 mm in all three directions. The results also show that CdTe strip detectors based PEM scanner can produce high resolution images for early diagnosis of breast cancer.

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Design and evaluation of the MAMMI dedicated breast PET

Cited by 107 publications

References 67 publications

Positron Emission Mammography Image Interpretation for Reduced Image Count Levels

Positron Emission Mammography Image Interpretation for Reduced Image Count Levels

Time of flight measurements based on FPGA using a breast dedicated PET

Modeling and simulation of Positron Emission Mammography (PEM) based on double-sided CdTe strip detectors

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