Design and Evaluation of Tinidazole Dental Implants

Karunakar, B; Sabu, K.; Udupa, N.; Varma, Beena

doi:10.3109/03639049409050194

Cited by 3 publications

(1 citation statement)

References 3 publications

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“…To increase the adherence between the bases and the oral tissues, polymers with bioadhesive properties are selected as gelling agent [5], [6] .Mucoadhesive polymers of natural, semisynthetic or synthetic origin are able to form hydro gel which swell in presence of water and physically entrap drug molecule for subsequent slow release by diffusion or erosion. Among bioadhesive polymer, poly (acrylic acid)-based polymers like carbopol and polycarbophil, cellulose derivatives like sodium carboxymethylcellulose, hydroxy propylmethyl cellulose and methyl cellulose and natural gum like xanthan gum and guar gum [4] Several buccal devices were formulated with tinidazole which is close analogue to metronidazole for treatment of periodentitis like tinidazole dental implant and tinidazole stilus [7,8] .…”

Section: Introductionmentioning

confidence: 99%

Some Variable Affecting Formulationof Tinidazole Mucoadhesive Oral Gel

Sulayman

2011

AJPS

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Tinidazole (TZ) is an antibacterial drug used for treatment of periodentitis.More benefit may be obtained by the application of a localized oral drug delivery system consist of mucoadhesive polymers which increase the contact time between the base and the oral tissue. Different gel formulations were prepared using the bioadhesive polymers carbomer 941, sodium caroxymethylcellulose (SCMC), and guar gum. The influence of polymer type and polymers blend in varying ratio on the viscosity, bioadhesive strength, swelling index and drug release were evaluated. SCMC based gel showed fastest release in comparison with carbomer and guar gum based gel. Using polymer blend of SCMC with either carbomer or guar gum resulted in a modification of both release and physical properties. The release of TZ was decreased with increasing amount of carbomer and guar gum and decreasing amount of SCMC. And increasing the viscosity of the gel formulations resulted in a retardation effect on the release of the drug. The study also showed that formulas containing carbomer exhibited maximum swelling values with lower release rates and best mucoadhesion.

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Section: Introductionmentioning

confidence: 99%

Some Variable Affecting Formulationof Tinidazole Mucoadhesive Oral Gel

Sulayman

2011

AJPS

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Controlled and targeted drug delivery strategies towards intraperiodontal pocket diseases

2000

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Advances in the understanding of the aetiology, epidemiology, pathogenesis and microbiology of periodontal pocket flora have revolutionized the strategies for the management of intraperiodontal pocket diseases. Intra‐pocket, sustained release, drug delivery devices have been shown to be clinically effective in the treatment of periodontal infections. Several degradable and non‐degradable devices are under investigation for the delivery of antimicrobial agents into the periodontal pocket including non‐biodegradable fibres, films (biodegradable and non‐biodegradable), bio‐absorbable dental materials, biodegradable gels/ointments, injectables and microcapsules. With the realization that pocket bacteria accumulate as biofilms, studies are now being directed towards eliminating/killing biofilm concentrations rather than their planktonic (fluid phase) counterparts. Intraperiodontal pocket drug delivery has emerged as a novel paradigm for the future research. Similarly, bioadhesive delivery systems are explored that could significantly improve oral therapeutics for periodontal disease and mucosal lesions. A strategy is to target a wide range of molecular mediators of tissue destruction and hence arrest periodontal disease progression. Research into regenerating periodontal structures lost as a result of disease has also shown substantial progress in the last 25 years.

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Preparation and evaluation of periodontal films based onpolyelectrolyte complexformation

Kassem

Ismail

Naggar

et al. 2014

Pharmaceutical Development and Technology

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Local intra-pocket drug delivery devices can provide an effective concentration of the antimicrobial agent at the site of action with avoidance of undesirable side effects. This study explored the application of chitosan-alginate and chitosan-pectin polyelectrolyte complex (PEC) films as drug release regulators for tetracycline HCl (Tc) to treat periodontal pockets. Periodontal films with 1:1 Tc:PEC ratio were prepared using 1:1 chitosan (Ch) to sodium alginate (A) or 1:3 Ch to pectin (P). The scanning electron microscope showed acceptable film appearance and differential scanning calorimetry analysis confirmed complex formation. The in vitro release studies for both films showed a burst drug release, followed by prolonged release for 70 h. A prolonged antibacterial activity of both films against Staphylococcus aureus ATCC 6538 was observed over a period of 21 days. Aging studies indicated that the five months storage period in freezer did not significantly influence the drug release profile or the antibacterial activity of both films. Clinical evaluation showed a significant reduction in pocket depth (p < 0.0001) to their normal values (≤3 mm). PEC films could be exploited as a prolonged drug release devices for treatment of periodontal pockets.

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Design and Evaluation of Tinidazole Dental Implants

Cited by 3 publications

References 3 publications

Some Variable Affecting Formulationof Tinidazole Mucoadhesive Oral Gel

Some Variable Affecting Formulationof Tinidazole Mucoadhesive Oral Gel

Controlled and targeted drug delivery strategies towards intraperiodontal pocket diseases

Preparation and evaluation of periodontal films based onpolyelectrolyte complexformation

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