Design and fabrication of a magnetically actuated non-invasive reusable drug delivery device

Abstract

We present a novel approach of designing and fabricating a noninvasive drug delivery device which is capable of delivering the drug to the target site in a controlled manner. The device utilizes a reservoir which can be reused once the drug has completely diffused from it. This micro-reservoir based fabricated device has been successfully tested using niosomes of insulin drug filled in, which was then sealed with a magnetic membrane of 20 µm thick and was actuated by applying magnetic field. The deflection of the membrane on application of magnetic field results in the drug release from the reservoir. The discharge of the drug solution and the release rates was controlled by external magnetic field. The simulation of the membrane deflection using COMSOL software was carried out to optimize the concentration of the ferrous nanopowder in PDMS matrix. The characterization of the devices was implemented in-vitro on water and in-vivo on Wistar rats. It was also validated using high-performance liquid chromatography (HPLC) by observing characteristic peak of insulin. The blood samples showed the retention time of 2.79 min at λ of 280 nm which further authenticated the effectiveness of the proposed work. This noninvasive fabricated device provides reusability, precise control and can enable the patient or a physician to actively administrate the drug when required.

In Vitro Characterization of Mems Based Piezoelctrically Actuated Drug Delivery Device for Biomedical Applications

“…Unlike the conventional drug delivery devices, the fabricated Piezoelctrically actuated device can be used to deliver the drug to a specific target [16][17][18]. The PDMS membrane and the reservoir are made hydrophilic by argon plasma treatment, in order to prevent the adsorption of the drug on the PDMS surface.…”