Design and fabrication of bone tissue scaffolds based on <scp>PCL</scp>/<scp>PHBV containing</scp> hydroxyapatite nanoparticles: <scp>dual‐leaching</scp> technique

Nahanmoghadam, Amir; Asemani, Maryam; Goodarzi, Vahabodin; Ebrahimi‐Barough, Somayeh

doi:10.1002/jbm.a.37087

Cited by 43 publications

(27 citation statements)

References 31 publications

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“…Solvent-casting and particulate-leaching technique [102] Compressive strength:≈0.90 MPa, Compressive modulus:≈2.80 MPa, Porosity: 70% About 6.0% mass loss after 12 weeks Saos-2 Cells maintained their adherence to PCL scaffold and grown on the scaffold Bone scaffold PLGA Electrospinning [103] Tensile strength:≈132 MPa, Young's modulus:≈4050 MPa About27.6 % mass loss after 28 days…”

Section: Bone Scaffoldmentioning

confidence: 99%

Structural and Functional Adaptive Artificial Bone: Materials, Fabrications, and Properties

Feng

Zhao

Tang

et al. 2023

Adv Funct Materials

118

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It is an urgent need that defect repair can develop from simple device fixation to living tissue reconstruction, from short life function replacement to permanent regeneration repair. At present, bone transplantation has become the second largest transplantation surgery after blood transfusion, and artificial bone transplantation generates great hope for the repair and treatment of bone defect. In order to repair bone defect, artificial bone must have good biological properties and sufficient mechanical properties, and it should also have the shape matching to bone defect site and the connected porous structure. For structures and properties requirements of artificial bone, in this review three major challenges faced by artificial bone transplantation are systemtically analyzed and current methods and strategies to address these issues are discussed: 1) the need for developing a type of bone scaffold material with both biological and mechanical properties, 2) the need for realizing the controllable fabrication of individual shape and multistage pore structure of bone scaffold, 3) the need for realizing the transformation from man‐made structure to biological structure. Besides, it summarizes the advantages and disadvantages of these methods and discusses the potential future directions of structural and functional adaptive artificial bone for bone defect regeneration.

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Section: Bone Scaffoldmentioning

confidence: 99%

Structural and Functional Adaptive Artificial Bone: Materials, Fabrications, and Properties

Feng

Zhao

Tang

et al. 2023

Adv Funct Materials

118

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“…Scaffolds with dual porosity have been prepared using the SCPL method alone using the same porogen or different porogens with two different size ranges. [65,96,[130][131][132][133][134][135][136] This method is applicable for polymer, glass or ceramic, and glass or ceramic/polymer composite scaffolds and has great control over pore size as the size of the porogen used determines it.…”

Section: Scplmentioning

confidence: 99%

Glass, Ceramic, Polymeric, and Composite Scaffolds with Multiscale Porosity for Bone Tissue Engineering

Jeyachandran

Cerruti

2023

Adv Eng Mater

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Porosity affects performance of scaffolds for bone tissue engineering both in vitro and in vivo. Macropores (i.e., pores with a diameter >100 μm) are essential for cellular infiltration; micropores (i.e., pores with a diameter of 1–10 μm) promote cell adhesion and facilitate nutrient absorption. Scaffolds containing both macropores and micropores exploit the advantages of both pore sizes and have excellent osteogenic properties. Nanopores (i.e., pores with a diameter of 1–50 nm) can be included as well, to improve cell–material interactions by further enhancing the surface area of the scaffold. This article reviews fabrication techniques and properties of scaffolds with multiscale porosity, focusing on glass, ceramic, polymeric, and composite scaffolds. After discussing the structure of bone and how it inspired scaffolds for bone tissue engineering, pore nomenclature is introduced. Then, the techniques used to induce multiscale porosity, the nature of the pores created, and the effects of scaffold porosity on mechanical properties and biological activity of the scaffolds are discussed. The review concludes by providing an outlook for this field, including advancements that are made possible by computational modeling and artificial intelligence.

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“…This technique has been used to generate porous polymers such as polylactide/nHA and poly (hydroxybutyrate-co-hydroxyvalerate) PHBV/ polycaprolactone PCL/nHA offering success as scaffolds for bone tissue engineering 55,56 .…”

Section: Salt Leachingmentioning

confidence: 99%

Alveolar Bone Regeneration Via Utilization of Nanohydroxyapatite Scaffolds: A Review

2022

PJMD

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The complete architectural and functional rehabilitation of periodontium owes to the integrity of alveolar bone. The inherent shortcomings of traditional gold standard regenerative procedures like autografting, xenografting, allografting and alloplasting lead to the evolutionary combination of Tissue Engineering/Regenerative Medicine (TE/RM) and nanotechnology for bone repair. Nanotechnology enables the fabrication of either nanoparticles, nanofibers or nanocomposites based on three-dimensional scaffolds. However, it will incorporate vital cells and growth factors in various combinations, to simulate a conducive oral environment of the extracellular matrix (ECM) and empower cells in the bone to regulate in-vivo osteogenesis. The advantageous combination of structural similarity of nanohydroxyapatite (nHA) Scaffolds to the alveolar bone with favorable particle size, response rate, tissue factors and bio factor, makes it attractive for TE/RM. Relevant keywords from 2010-2021 studies were used to retrieve data from "PubMed" and "Google Scholar". This review aims to summarize the cumulative knowledge of commercially available nanohydroxyapatite scaffolds for utilization in alveolar bone augmentation, regeneration of implant osteointegration by their fabrication techniques, advantages, components, types, interaction with various components and particular application of each type for in vivo alveolar bone regeneration. Therefore, nHA scaffolds possess significant osteoconductive and osteoinductive effects on structural similarities to the composition, adhesion and differentiation of bone-forming cells.

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Design and fabrication of bone tissue scaffolds based on PCL/PHBV containing hydroxyapatite nanoparticles: dual‐leaching technique

Cited by 43 publications

References 31 publications

Structural and Functional Adaptive Artificial Bone: Materials, Fabrications, and Properties

Structural and Functional Adaptive Artificial Bone: Materials, Fabrications, and Properties

Glass, Ceramic, Polymeric, and Composite Scaffolds with Multiscale Porosity for Bone Tissue Engineering

Alveolar Bone Regeneration Via Utilization of Nanohydroxyapatite Scaffolds: A Review

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