Design and fabrication of hybrid triple-responsive κ-carrageenan-based nanospheres for controlled drug delivery

Geyik, Gülcan; Işıklan, Nuran

doi:10.1016/j.ijbiomac.2021.10.007

Cited by 24 publications

(6 citation statements)

References 53 publications

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“…The most common materials for such biopolymers are carboxymethyl cellulose (CMC), poly(amino acids), starch [7] poly(acrylamide) (PAAm), polydopamine, poly(lactide), poly(diethylaminoethyl methacrylate) (PDEAEMA), poly (acrylic acid) (PAA), poly(methacrylic acid) (PMAA), poly (ɛ-caprolactone) (PCL), gelatine, poly(dimethylaminoethyl methacrylate) (PDMAEMA), poly(2-methacryloyloxyethyl phosphorylcholine), albumin, polyvinyl alcohol (PVA), alginate, chitosan, carrageenan, and polyethylene glycol (PEG) [3,4,[7][8][9][10][11][12][13][14][15][16][17]. As given in Figure 4, alginate [18,19], chitosan [20][21][22][23], carrageenan [24][25][26][27] were studied, for instance, in the immobilization of enzymes (e.g. lactase), drug delivery systems, encapsulation of food (e.g.…”

Section: Applications Of Biopolymersmentioning

confidence: 99%

Introductory Chapter: Introduction to Biocomposites – New Insights

Elnashar¹,

Karakuş²

2023

Biocomposites - Recent Advances

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Recent developments in the study of bio-based nanostructures, with an emphasis on the environmentally sustainable production of biocomposites, have tremendously benefited biomedical applications. The low-cost, environmentally beneficial method of creating biocomposites with biodegradable and biocompatible polymers currently has a variety of advantages. The advantages of pH and temperature sensitive dual-stimuli responsive nano-systems should be investigated by next-generation drug delivery systems using in vitro or in vivo methods. These discoveries imply that additional research in this field is required given the lack of experimental knowledge and understanding of drug release systems, bio-sensing mechanism, and therapeutic effects of these biocomposites.

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Section: Applications Of Biopolymersmentioning

confidence: 99%

Introductory Chapter: Introduction to Biocomposites – New Insights

Elnashar¹,

Karakuş²

2023

Biocomposites - Recent Advances

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“…[167] Copyright 2021, Elsevier B.V. magnetic hydrogel nanocomposites are highly effective for the improvement of site-precise or time-managed drug transport structures. [171,172] Furthermore, MNPs provide capabilities to the subsequent nanoparticles that may be useful for other biomedical claims such as medicinal imaging. [164,173] The effect of magnetic iron oxide on the expansion and release properties of methylene blue.…”

Section: Carrageenan-based Hybrids With Magnetic/non-magnetic Nanocar...mentioning

confidence: 99%

“…[ 168,169 ] The potential advantage of these magnetic nanoparticles is the magnetically‐induced transference of drugs that provides topical drug delivery. [ 170,171 ] Additionally, by altering the external magnetic field, remote measured proclamation of the condensed therapeutic agent can be attained. Therefore, these magnetic hydrogel nanocomposites are highly effective for the improvement of site‐precise or time‐managed drug transport structures.…”

Section: Biomimicry Of Carrageenan‐based Hybrids With Nano‐structured...mentioning

confidence: 99%

Carrageenan‐Based Hybrids with Biopolymers and Nano‐Structured Materials for Biomimetic Applications

et al. 2022

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Carrageenan is an algal‐originated group of polysaccharides with unusual structural and functional capabilities, desired for different biomimetic applications due to their renewable, biocompatible, and biodegradable nature. Carrageenan‐based hybrids (nano‐/biocomposites) with different biopolymers and nano‐structured materials have been widely reported as potential candidates for bone/cartilage tissue engineering, delivery of drugs/bioactive ingredients, wound healing, and 3D bioprinting applications. Owning to the broad‐scale biomimetic applications of carrageenan‐based materials, this review aims to summarize carrageenan chemistry and distinct physicochemical features of biopolymeric and/or nanostructured materials‐based on carrageenans in a detailed manner. Herein, different biopolymers (such as chitosan, cellulose, starch, and alginates), and nano‐structured materials (such as silica nanoparticles, magnetic/non‐magnetic nanocarriers, graphene oxide nanoparticles, carbon nanotubes/nanorods, metal oxide nanoparticles) are comprehensively described in combination with carrageenan. However, carrageenan toxicity studies have presented major challenges that need to be addressed when using carrageenan‐based materials for biomedical and therapeutic purposes. Several existing challenges, prospects, and research recommendations are described at the end of this review.

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“…One such system is the nanosphere. Nanosphere is a nanoencapsulation method made by adding a polymer to envelop the active ingredients of drugs so that they are not exposed to the environment, which can damage it by trapping the drug in its interior structure, binding to it, or absorbing it on its surface and can provide control release [3].…”

Section: Introductionmentioning

confidence: 99%

Effect of Polymer Concentration and Surfactants on Physical Characteristics, Drug Release and Antioxidant Activity of Glutathione-Kappa Carrageenan Nanospheres

NAILUFA,

WIDJAJA

2024

Int J App Pharm

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Objective: Glutathione is one of the antioxidants widely used as an antiaging and skin lightener. Glutathione at a dose of 250 mg/d orally proved useful as an antiaging. At the same time, glutathione topical night cream is effective at a dose of 0.1% for the skin of Indonesian women. Glutathione is one of the antioxidants that has easily oxidized properties in storage. Research purpose to optimize the concentration of kappa carrageenan polymer and surfactan to obtain the optimal physical characteristics of nanosphere system analyzed based on size, PDI, yield, drug loading, entrapment efficiency, dissolution and antioxidant activity. Methods: The most commonly used method of making nanospheres is ionotropic gelation because it has proven effective, easy, and easy to apply. Ionotropic gelation is depend on the tendency of polyelectrolytes to cross connect to develop hydrogel beads often called gelispheres in the existence of counter ions. Nanospheres were prepared by aerosolization ionotropic gelation technique followed by freeze-drying. This method uses carrageenan polymers of 0.5% and 1.0% with the addition of surfactant as a stabilizer. Evaluation parameters are particle size, entrapment efficiency, drug loading, drug release and antioxidant activity. Results: The results of the nanospheres obtained were tested physically and drug activity. Nanospheres successfully formed, with size 382.67±52.24 nm, F2 325.20±4.62 nm, F3 495.39±30.61 nm, and F4 409.80±4.11 nm. The greater the polymer concentration, the greater the value of entrapment efficiency and drug content in the nanosphere. The morphology of the nanosphere is quite good, spherical, with a smooth surface. The release profile shows that glutathione release is quite good but takes a long time, namely F1 73.91±2.17%, F2 75.91±2.76%, F3 78.56±2.82%, and F4 79.56±1.34% in 480 min or 8 h. Antioxidant activity of glutathione-Kappa carrageenan nanospheres with the DPPH method showed that nanospheres have medium or medium category antioxidant activity. Conclusion: The most optimal formula is F4 with 1% kappa-carrageenan concentration and 0.6% KCl.

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Design and fabrication of hybrid triple-responsive κ-carrageenan-based nanospheres for controlled drug delivery

Cited by 24 publications

References 53 publications

Introductory Chapter: Introduction to Biocomposites – New Insights

Introductory Chapter: Introduction to Biocomposites – New Insights

Carrageenan‐Based Hybrids with Biopolymers and Nano‐Structured Materials for Biomimetic Applications

Effect of Polymer Concentration and Surfactants on Physical Characteristics, Drug Release and Antioxidant Activity of Glutathione-Kappa Carrageenan Nanospheres

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