Design and implementation of a portable colposcope Mueller matrix polarimeter

Gonzalez, Mariacarla; Montejo, Karla A.; Krupp, Karl; Srinivas, Vijaya; DeHoog, Edward; Madhivanan, Purnima; Ramella‐Roman, Jessica C.

doi:10.1117/1.jbo.25.11.116006

Cited by 19 publications

(15 citation statements)

References 41 publications

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“…The results agreed with polarimetric imaging of healthy cervices, where there are high depolarization values for all patients. There was an exception for one patient diagnosed with a polyp, which showed lower depolarization values (as expected) [ 56 , 57 ].…”

Section: Cervical Imaging Targeted For Neoplastic Detectionsupporting

confidence: 57%

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Cervical Imaging in the Low Resource Setting: A Review

et al. 2022

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Cervical cancer is one of the most significant global health inequities of our time and is the fourth most common cancer in women worldwide, disproportionally affecting developing countries where the disease burden is 84%. Sometimes referred to as preventable cancer, it progresses slowly, providing a window of time for routine screening in which pre-cancerous lesions can be identified and treated. The high mortality rate can be attributed to many reasons, including the high cost of cytology-based screening, lack of human resources to conduct screening, and inadequate preventive medicine services and systems. Due to its slow progression, early intervention is feasible with appropriate screening. However, the standard screening procedures require access to lab-based tests and physician expertise. Several imaging devices have been introduced in the literature to aid cervical screening in low-resource settings. This review details the instrumentation and clinical testing of devices currently deployed in low-resource locations worldwide. The devices' imaging, portability, illumination, and power requirements (among other metrics) are documented with specifics of human pilot studies conducted with these tools.

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Section: Cervical Imaging Targeted For Neoplastic Detectionsupporting

confidence: 57%

“…The device is noninvasive, although a speculum is needed to visualize the cervix. The cost of the device is approximately $2000 [ 56 ]. A picture of the device can be seen in Figure 4 .…”

Section: Cervical Imaging Targeted For Neoplastic Detectionmentioning

confidence: 99%

Cervical Imaging in the Low Resource Setting: A Review

et al. 2022

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“…7a (i), (ii), b (i)), in vivo bulk tissue polarimetry is geared towards applications 24 , 256 , 265 . Typical backscattering-mode polarimetry includes polarisation endoscopy 24 , reflection MM microscopy 16 , 266 , MM colposcopy 180 , 267 , wide-field handheld polarimetry 16 , and PS-OCT 268 (see Fig. 7a (iii), b (ii)), targeted to clinical diagnosis in vivo.…”

Section: Vectorial Information Analysis For Biomedical Applicationsmentioning

confidence: 99%

Polarisation optics for biomedical and clinical applications: a review

et al. 2021

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Many polarisation techniques have been harnessed for decades in biological and clinical research, each based upon measurement of the vectorial properties of light or the vectorial transformations imposed on light by objects. Various advanced vector measurement/sensing techniques, physical interpretation methods, and approaches to analyse biomedically relevant information have been developed and harnessed. In this review, we focus mainly on summarising methodologies and applications related to tissue polarimetry, with an emphasis on the adoption of the Stokes–Mueller formalism. Several recent breakthroughs, development trends, and potential multimodal uses in conjunction with other techniques are also presented. The primary goal of the review is to give the reader a general overview in the use of vectorial information that can be obtained by polarisation optics for applications in biomedical and clinical research.

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“…In this study, total reflectance was quantified along with analyzing the accuracy of results by calculating the structural similarity index, peak signal-to-noise ratio, and mean square error of the images. 35 Gonzalez et al 36 developed a low-cost snapshot Mueller matrix polarimeter for imaging the ex vivo pig cervix, which could be used for cervical screening in low-resource settings. The polarization properties were quantified using the Stokes vector, and the depolarization and retardance data were retrieved using Mueller matrix decomposition.…”

Section: Introductionmentioning

confidence: 99%

“…The polarization properties were quantified using the Stokes vector, and the depolarization and retardance data were retrieved using Mueller matrix decomposition. 36 Mueller matrix microscopy, as well as logarithmic decomposition and polarized Monte Carlo (MC) modeling, were proposed by Li et al 30 for qualitative and quantitative analysis of thin human skin tissues, for extracting the details about the tissue morphology, which is not provided by white-light microscopy.…”

Section: Introductionmentioning

confidence: 99%

Toward the development of a polarimetric tool to diagnose the fibrotic human ventricular myocardium

et al. 2022

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Significance: Optical polarimetry is an emerging modality that effectively quantifies the bulk optical properties that correlate with the anisotropic structural properties of cardiac tissues. We demonstrate the application of a polarimetric tool for characterizing healthy and fibrotic human myocardial tissues efficiently with a high degree of accuracy. Aim:The study was aimed to characterize the myocardial tissues from the left ventricle and right ventricle of N ¼ 7 control and N ¼ 10 diseased subjects. The diseased subjects were composed of two groups: N ¼ 7 with rheumatic heart disease (RHD) and N ¼ 3 with myxomatous valve (MV) disease.Approach: A portable, affordable, and accurate linear polarization-based diagnostic tool is developed to measure the degree of linear polarization (DOLP) of the myocardial tissues while working at a wavelength of 850 nm.Results: The sensitivity, specificity, and accuracy of the polarimetric tool in distinguishing the control group from the RHD group were found to be 73.33%, 76.92%, and 75%, respectively, and from the MV group were 91.6%, 62.5%, and 80%, respectively, which demonstrates the efficacy of the polarimetric tool to distinguish the healthy myocardial tissues from diseased tissues. Conclusions:We have successfully developed a polarimetric tool that can aid cardiologists in characterizing the myocardial tissues in conjunction with endomyocardial biopsy. This work should be followed up with experiments on a large cohort of control and diseased subjects. We intend to create and develop a probe to quantify the DOLP of in vivo heart tissue during surgery.

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Design and implementation of a portable colposcope Mueller matrix polarimeter

Cited by 19 publications

References 41 publications

Cervical Imaging in the Low Resource Setting: A Review

Cervical Imaging in the Low Resource Setting: A Review

Polarisation optics for biomedical and clinical applications: a review

Toward the development of a polarimetric tool to diagnose the fibrotic human ventricular myocardium

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