A 3W series LED constant current drive integrated circuit is designed in this paper. The driver can provide a constant current of 350mA for LED devices with over temperature and over voltage protection. When the power supply voltage fluctuates within ± 10%, the output driving current changes less than 5%; When the temperature of chip varies between 0 º C and 120 º C, the change in output driving current is less than 5%. The chip includes constant current drive, over temperature, and over voltage control circuits, as well as high-power driving NMOS devices. The control circuit consists of a bandgap voltage reference, an error amplifier, a sampling circuit. The bandgap voltage reference provides three reference voltages that are independent of temperature and power supply voltage; The sampling circuit and operational amplifier form a negative feedback circuit, allowing the sampling NMOS and power NMOS to operate at the same temperature and current density, so that the sampling current can more accurately reflect the changes in the output driving current of the power NMOS, and improve the control accuracy of the output driving current. By using a feedback control circuit, the sampling current tends to be constant, thereby achieving the goal of controlling the output driving current. The automatic adjustment of output current is achieved through over temperature and overvoltage circuits, which not only ensures the continuity of output current but also effectively ensures the safety of LED devices.