Design and implementation of fiber-based multiphoton endoscopy with microelectromechanical systems scanning

Tang, Shuo; Jung, Woonggyu; McCormick, Daniel T.; Xie, Tianwu; Su, Jianping; Ahn, Yeh‐Chan; Tromberg, Bruce J.; Chen, Zhongping

doi:10.1117/1.3127203

Cited by 106 publications

(74 citation statements)

References 23 publications

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“…The development of NLOM probe based on multiphoton excitation that uses a near infrared laser beam for imaging is in progress by several groups [20][21][22]. An important factor that limits the use of NLOM probe in clinical studies is the lack of a compactness and flexibility.…”

Section: Introductionmentioning

confidence: 99%

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Nonlinear optical microscopy of early stage (ICRS Grade-I) osteoarthritic human cartilage

Kumar

Grønhaug

Davies

et al. 2015

Biomed. Opt. Express

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Abstract:In a synovial joint, the articular cartilage is directly affected during the progression of Osteoarthritis (OA). The characterization of early stage modification in extra-cellular matrix of cartilage is essential for detection as well as understanding the progression of disease. The objective of this study is to demonstrate the potential and capability of nonlinear optical microscopy for the morphological investigation of early stage osteoarthritic cartilage. ICRS Grade-I cartilage sections were obtained from the femoral condyle of the human knee. The surface of articular cartilage was imaged by second harmonic generation and two-photon excited fluorescence microscopy. Novel morphological features like microsplits and wrinkles were observed, which would otherwise not be visible in other clinical imaging modalities (e.g., CT, MRI, ultrasound and arthroscope. The presence of superficial layer with distinct collagen fibrils parallel to the articular surface in 4 specimens out of 14 specimens, indicates that different phases of OA within ICRS Grade-I can be detected by SHG microscopy. All together, the observed novel morphologies in early stage osteoarthritic cartilage indicates that SHG microscopy might be a significant tool for the assessment of cartilage disorder.

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Section: Introductionmentioning

confidence: 99%

“…This demonstrates that the technique is compatible with in vivo investigation by the use of a miniaturized NLOM probe, which necessarily uses backscattered imaging. An endoscopic LOM probe is under development by several groups [20][21][22].…”

mentioning

confidence: 99%

Nonlinear optical microscopy of early stage (ICRS Grade-I) osteoarthritic human cartilage

Kumar

Grønhaug

Davies

et al. 2015

Biomed. Opt. Express

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“…In the presented area we must consider chromatic dispersion which causes femtosecond pulses to spread to picoseconds pulses when propagating in optical bers, thereby deteriorating the excitation eciency of TPF signals. Tang et al [5] have shown that dispersion of DC PCF broadens the 170 fs pulse to 2.5 ps. Therefore the management of dispersion is a critical issue in the design of TPF endoscopy.…”

Section: Introductionmentioning

confidence: 99%

Construction of Double Cladding Small Dispersion Photonic Crystal Fiber to Guide Ultrashort Pulse at 800 nm

Stawska

Bereś-Pawlik

2012

Acta Phys. Pol. A

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The methods using femtosecond lasers are very popular in the world recently. They are used for dierent research methods. We begin to use a multi-photon autouorescence method for cancer tissue detection. We plan to use this method with special photonic crystal ber optic sensors. We would like to use to this detection femtosecond oscillator for 800 nm region. However, according to our information there is no ber which can provide these femtosecond signals at 800 nm region without dispersion and nonlinear eect. Applying typical ber causes dispersion of guided signals. Therefore we are preparing suitably designed bers. Double-clad photonic bers can play a dual role of ultrashort pulse delivery and ecient collection of nonlinear optical signals. In the paper a new design of double cladding small dispersion photonic crystal ber is proposed. Simulations of both structure and dispersion in proposed bers are presented.

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“…However, this approach compromises co-registration of the two modalities. Other reported approaches have used single Ti-Sapphire broadband femtosecond (fs) laser sources for both spectral domain OCT and multiphoton excited fluorescence imaging systems [25][26][27][28][29][30][31][32]. Double-clad fiber (DCF) can also provide a common path for the two modalities that ensures co-registration.…”

Section: Introductionmentioning

confidence: 99%

A high-efficiency fiber-based imaging system for co-registered autofluorescence and optical coherence tomography

Pahlevaninezhad¹,

Lee²,

Shaipanich³

et al. 2014

Biomed. Opt. Express

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Abstract:We present a power-efficient fiber-based imaging system capable of co-registered autofluorescence imaging and optical coherence tomography (AF/OCT). The system employs a custom fiber optic rotary joint (FORJ) with an embedded dichroic mirror to efficiently combine the OCT and AF pathways. This three-port wavelength multiplexing FORJ setup has a throughput of more than 83% for collected AF emission, significantly more efficient compared to previously reported fiber-based methods. A custom 900 µm diameter catheter -consisting of a rotating lens assembly, double-clad fiber (DCF), and torque cable in a stationary plastic tube -was fabricated to allow AF/OCT imaging of small airways in vivo. We demonstrate the performance of this system ex vivo in resected porcine airway specimens and in vivo in human on fingers, in the oral cavity, and in peripheral airways. 36. S. Liang, A. Saidi, J. Jing, G. Liu, J. Li, J. Zhang, C. Sun, J. Narula, and Z. Chen, "Intravascular atherosclerotic imaging with combined fluorescence and optical coherence tomography probe based on a double-clad fiber combiner," J.

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Design and implementation of fiber-based multiphoton endoscopy with microelectromechanical systems scanning

Cited by 106 publications

References 23 publications

Nonlinear optical microscopy of early stage (ICRS Grade-I) osteoarthritic human cartilage

Nonlinear optical microscopy of early stage (ICRS Grade-I) osteoarthritic human cartilage

Construction of Double Cladding Small Dispersion Photonic Crystal Fiber to Guide Ultrashort Pulse at 800 nm

A high-efficiency fiber-based imaging system for co-registered autofluorescence and optical coherence tomography

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