This study aimed to further enhance and enrich users’ visual experience, provide users with a more infectious image sense, and further promote the development of multidimensional, virtualized, and interactive graphic advertising design applications. This study presents a design idea of print advertisement based on computer image interactive virtual technology. Based on the in-depth analysis of the multidimensional expression of plane image interactive virtualization, this idea carries out interactive virtual design with the help of interactive virtual image segmentation algorithm and plane advertising image element optimization technology. Through the test of image interactive edge extraction function on MATLAB platform, the simulation results show that the edge width of single side extraction results with different gray levels of the same width and different widths of the same gray level are 9 pixels, the gray values are 5a0, 110, and 200, respectively, and the edge width corresponds to 3, 9, and 15 pixels, respectively. The results show that the system can effectively enhance the image definition and obtain better print advertising design effect.