Design and Implementation of Structured Clinical Documentation Support Tools for Treating Stroke Patients

Simon, Kelly Claire; Munson, Richard; Ong, Archie; Gil, Fulvio R.; Campanella, Franco; Hillman, Laura; Lai, Rebekah; Chesis, Richard; Tideman, Samuel; Vazquez, Rosa Maria; Meyers, Steven; Frigerio, Roberta; Maraganore, Demetrius M.

doi:10.1016/j.jstrokecerebrovasdis.2019.01.011

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Cited by 3 publications

References 15 publications

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Development and implementation of an evidence-based biofield therapy standardized documentation tool

Guillory,

Blue,

Casken

et al. 2024

European Journal of Integrative Medicine

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Development and implementation of an evidence-based biofield therapy standardized documentation tool

Guillory,

Blue,

Casken

et al. 2024

European Journal of Integrative Medicine

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Lipid trajectories improve risk models for Alzheimer’s disease and mild cognitive impairment

Chase,

Frigerio,

Yucus

et al. 2025

Journal of Lipid Research

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Lipid Trajectories Improve Risk Models for Alzheimer’s Disease and Mild Cognitive Impairment

Chase,

Frigerio,

Yucus

et al. 2024

Preprint

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To assess the relationship between lipids and cognitive dysfunction, we retrospectively analyzed blood lipid levels in clinically well characterized individuals with stable mild cognitive impairment (MCI) or Alzheimer's disease (AD) over the decade prior to first cognitive symptoms. In this case/control cohort study, AD and MCI cases were diagnosed using DSM.IV criteria; MCI cases had not progressed to dementia for 5 years; and controls were propensity matched to cases at age of symptom onset (MCI: 116 cases, 435 controls; AD: 215 cases, 483 controls). Participants were grouped based on longitudinal trajectories and quintile of variability independent of the mean (VIM) for total cholesterol, HDLC, LDLC, nonHDLC and ln(triglycerides). Models for the risk of cognitive dysfunction evaluated trajectory and VIM groups, APOE genotype, polygenic risk scores (PRS) for AD and lipid levels, age, comorbidities, and longitudinal correlates of blood-lipid concentrations. Lower HDLC trajectories (OR = 3.8, 95% CI = 1.3, 11.3) and the lowest VIM quintile of nonHDLC (OR = 2.2, 95% CI = 1.3, 3.0) were associated with higher MCI risk. Lower HDLC trajectories (OR = 3.0, 95% CI = 1.6, 5.7) and the lowest VIM quintile of total cholesterol (OR = 2.4, 95% CI = 1.5, 3.9) were associated with higher AD risk. The inclusion of lipid-trajectory and VIM groups improved risk-model predictive performance independent of APOE genotype or PRS for AD and lipid levels. These results provide an important real world perspective on the influence of lipid metabolism and blood lipid levels on the development of stable MCI and AD.

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Design and Implementation of Structured Clinical Documentation Support Tools for Treating Stroke Patients

Cited by 3 publications

References 15 publications

Development and implementation of an evidence-based biofield therapy standardized documentation tool

Development and implementation of an evidence-based biofield therapy standardized documentation tool

Lipid trajectories improve risk models for Alzheimer’s disease and mild cognitive impairment

Lipid Trajectories Improve Risk Models for Alzheimer’s Disease and Mild Cognitive Impairment

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