Design and manufacture of a high precision personalized electron bolus device for radiation therapy

Aldawood, Faisal Khaled; Chang, S; Desai, Salil

doi:10.1002/mds3.10077

Cited by 12 publications

(6 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A 3D printer builds an object by depositing the desired material layer-by-layer. The biomedical device industry has seen a rapid rise of 3D printing technologies in tissue engineering implants in recent years [ 153 , 154 , 155 , 156 , 157 , 158 , 159 , 160 , 161 , 162 , 163 , 164 ]. In 2019, Johnson et al fabricated the first MN master using a commercial 3D printer [ 60 ].…”

Section: Mn Manufacturing Methodsmentioning

confidence: 99%

A Comprehensive Review of Microneedles: Types, Materials, Processes, Characterizations and Applications

2021

Self Cite

View full text Add to dashboard Cite

Drug delivery through the skin offers many advantages such as avoidance of hepatic first-pass metabolism, maintenance of steady plasma concentration, safety, and compliance over oral or parenteral pathways. However, the biggest challenge for transdermal delivery is that only a limited number of potent drugs with ideal physicochemical properties can passively diffuse and intercellularly permeate through skin barriers and achieve therapeutic concentration by this route. Significant efforts have been made toward the development of approaches to enhance transdermal permeation of the drugs. Among them, microneedles represent one of the microscale physical enhancement methods that greatly expand the spectrum of drugs for transdermal and intradermal delivery. Microneedles typically measure 0.1–1 mm in length. In this review, microneedle materials, fabrication routes, characterization techniques, and applications for transdermal delivery are discussed. A variety of materials such as silicon, stainless steel, and polymers have been used to fabricate solid, coated, hollow, or dissolvable microneedles. Their implications for transdermal drug delivery have been discussed extensively. However, there remain challenges with sustained delivery, efficacy, cost-effective fabrication, and large-scale manufacturing. This review discusses different modes of characterization and the gaps in manufacturing technologies associated with microneedles. This review also discusses their potential impact on drug delivery, vaccine delivery, disease diagnostic, and cosmetics applications.

show abstract

Section: Mn Manufacturing Methodsmentioning

confidence: 99%

A Comprehensive Review of Microneedles: Types, Materials, Processes, Characterizations and Applications

2021

Self Cite

View full text Add to dashboard Cite

show abstract

“…Lately, additive manufacturing, more commonly known as 3D printing, has rapidly been gaining attention as a means of manufacturing microneedles and molds [192]. In fact, the biomedical device industry has witnessed a swift adoption of 3D printing technologies for tissue engineering implants in recent years [256][257][258][259][260][261].…”

Section: Additive Manufacturingmentioning

confidence: 99%

Microneedles Patch: Design, Fabrication and Applications

Oliveira,

Teixeira,

Oliveira

et al. 2024

Preprint

View full text Add to dashboard Cite

The delivery of therapeutical molecules through the skin, particularly to its deeper layers is impaired due to the stratum corneum layer, which acts as barrier to foreign substances. Thus, for the past years, scientists have focused on the development of more efficient methods to deliver molecules to skin distinct layers. Microneedles, as a new class of biomedical devices, consists on an array of microscale needles. This particular biomedical device had been drawing attention due to their ability to breach the stratum corneum, forming micro-conduits to facilitate the passage of therapeutical molecules. The microneedle device has several advantages over conventional methods, such as better medication adherence, easiness and painless self-administration. Moreover, it is possible to deliver the molecules swiftly or over time. Microneedles can vary in shape, size and composition. The design process of a microneedle device must take in account several factors, like the location delivery, the material and manufacturing process. Microneedles have been used in a large number of fields from drug and vaccine application, cosmetics, therapy, diagnosis, tissue engineering, sample extraction, cancer research, wound healing, among others.

show abstract

“…AM is a highly adaptable manufacturing technique that is used to fabricate 3D structures directly from computer-aided design model files in a layer-by-layer fashion, with minimal material wastage and a high degree of freedom. AM has accelerated significant transformations across many domains, such as macro/microarchitectures, biomedical devices, wearable biosensors, flexible sensors, integrated devices, patient-specific treatment, and microfluidics [40][41][42][43][44][45][46][47][48][49][50][51][52][53][54]. The fusion of AM with wearable biosensors enables groundbreaking development in the realm of customized biomedicine, healthcare diagnostics, and treatment [55][56][57][58][59][60][61][62][63][64][65][66][67].…”

Section: Introductionmentioning

confidence: 99%

“…Due to some of the significant limitations of 3D printing technologies such as strength competence and functionality, the commercialization of 3D-printed objects is not feasible yet. Thus, one of the propitious approaches is to incorporate nanoparticles or fillers into the polymer to reinforce a 3D-printed object [50,[71][72][73][74]. Lately, extensive research has been conducted to develop more functional structures by incorporating nanoparticle materials [43,69,[75][76][77][78][79][80][81][82][83].…”

Section: Introductionmentioning

confidence: 99%

The 3D Printing of Nanocomposites for Wearable Biosensors: Recent Advances, Challenges, and Prospects

Parupelli,

Desai

2023

Bioengineering

Self Cite

View full text Add to dashboard Cite

Notably, 3D-printed flexible and wearable biosensors have immense potential to interact with the human body noninvasively for the real-time and continuous health monitoring of physiological parameters. This paper comprehensively reviews the progress in 3D-printed wearable biosensors. The review also explores the incorporation of nanocomposites in 3D printing for biosensors. A detailed analysis of various 3D printing processes for fabricating wearable biosensors is reported. Besides this, recent advances in various 3D-printed wearable biosensors platforms such as sweat sensors, glucose sensors, electrocardiography sensors, electroencephalography sensors, tactile sensors, wearable oximeters, tattoo sensors, and respiratory sensors are discussed. Furthermore, the challenges and prospects associated with 3D-printed wearable biosensors are presented. This review is an invaluable resource for engineers, researchers, and healthcare clinicians, providing insights into the advancements and capabilities of 3D printing in the wearable biosensor domain.

show abstract

Design and manufacture of a high precision personalized electron bolus device for radiation therapy

Cited by 12 publications

References 32 publications

A Comprehensive Review of Microneedles: Types, Materials, Processes, Characterizations and Applications

A Comprehensive Review of Microneedles: Types, Materials, Processes, Characterizations and Applications

Microneedles Patch: Design, Fabrication and Applications

The 3D Printing of Nanocomposites for Wearable Biosensors: Recent Advances, Challenges, and Prospects

Contact Info

Product

Resources

About