Design and manufacturing a tubular structures based on poly(ɛ-caprolactone) / poly(glycerol-sebacic acid) biodegradable nanocomposite blends: suggested for applications in the nervous, vascular and renal tissue engineering

Davoodi, Behnam; Goodarzi, Vahabodin; Hosseini, Hadi; Tirgar, Mahtab; Shojaei, Shahrokh; Asefnejad, Azadeh; Saeidi, Ardeshir; Oroojalian, Fatemeh; Benisi, Soheila Zamanlui

doi:10.1007/s10965-021-02881-8

Cited by 12 publications

(2 citation statements)

References 44 publications

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“…Moreover, hydrophobic and hydrophilic macromolecules can be encapsulated in polyester‐based polymers. Furthermore, natural biopolymers demonstrate benefits, such as low toxicity, biodegradability, abundance and biocompatibility (Davoodi et al., 2022 ). The most common polysaccharides in nano‐pharmacology are chitosan, dextran, agarose, hyaluronic acid and protein polymers, such as albumin, gelatin or soy (Cordeiro et al., 2015 ).…”

Section: Type Of Nanoparticles and Their Applicationsmentioning

confidence: 99%

Current status of nano‐vaccinology in veterinary medicine science

Sadr,

Poorjafari Jafroodi,

Haratizadeh

et al. 2023

Veterinary Medicine & Sci

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Vaccination programmes provide a safe, effective and cost‐efficient strategy for maintaining population health. In veterinary medicine, vaccination not only reduces disease within animal populations but also serves to enhance public health by targeting zoonoses. Nevertheless, for many pathogens, an effective vaccine remains elusive. Recently, nanovaccines have proved to be successful for various infectious and non‐infectious diseases of animals. These novel technologies, such as virus‐like particles, self‐assembling proteins, polymeric nanoparticles, liposomes and virosomes, offer great potential for solving many of the vaccine production challenges. Their benefits include low immunotoxicity, antigen stability, enhanced immunogenicity, flexibility sustained release and the ability to evoke both humoral and cellular immune responses. Nanovaccines are more efficient than traditional vaccines due to ease of control and plasticity in their physio‐chemical properties. They use a highly targeted immunological approach which can provide strong and long‐lasting immunity. This article reviews the currently available nanovaccine technology and considers its utility for both infectious diseases and non‐infectious diseases such as auto‐immunity and cancer. Future research opportunities and application challenges from bench to clinical usage are also discussed.

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Section: Type Of Nanoparticles and Their Applicationsmentioning

confidence: 99%

Current status of nano‐vaccinology in veterinary medicine science

Sadr,

Poorjafari Jafroodi,

Haratizadeh

et al. 2023

Veterinary Medicine & Sci

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“…The properties of this new material were carefully investigated in research works such as Aghajan et al [14], Golbaten-Mofrad et al [15], and Yoon et al [16]. In a similar study, PGS/PCL blends with some nanoparticles was prepared, and their unknown properties were analyzed [17,18].…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Characterization of Bio-nanocomposites Based on Poly(Glycerol Itaconic acid) (PGIt) and Using Poly(ɛ- caprolactone) diol (PCL-diol) as Macro Crosslinkers containing Cloisite Na + to application in Tissue engineering

Mahdavi

Zahedi

Goodarzi

2023

Preprint

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Biomaterials are a crucial issue in the field of tissue engineering. Two types of polymeric biomaterials, such as Poly(glycerol Itaconic acid) (PGIt) and Poly(ɛ-caprolactone) diol (PCL-diol), were synthesized by polycondensation and ring opening polymerization (ROP) respectively. The PCL-diol was selected as a minor phase with 30 and 50 wt.%, and Closite-Na+ was selected as the nanophase with a constant amount of 5 wt.%. Molecular structures PGIt and PCL-diol were analyzed by FTIR, 1H-NMR, and GPC techniques. Microstructures showing the presence of PCL-diol in the PGIt have not created compatible morphologies, albeit the presence of clay nanoparticles has helped to achieve the proper morphologies. Low angle XRD showed exfoliated, and intercalated morphologies can be predicted to pure PGIt and PGIt70PCLdiol30Clay5 samples. Mechanical analysis showed that Young’s modulus and elongation at the break of PGIt50PCLdiol50Clay5 and PGIt100 samples were higher than other samples. DMTA analysis showed that adding PCL-diol into the PGIt increased glass transition temperature (Tg) and storage modulus at 37oC. The master curve of the studied samples was prepared by the WLF equation at body temperature. Hydrocatalytical degradation, contact angles, and MTT analysis showed that all samples behave well in biological conditions. Cell adhesion, Dapi, and Alizarin red analysis were carried out on the selected samples, and their results showed that the presence of PCL-diol and Clay into the PGIt has improved the biological behavior of the sample and PGIt50PCLdiol50Clay5 shows just behavior.

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Healing Clays Structure and Functions

Madanayake¹,

Adassooriya²

2023

Medical Geology

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Design and manufacturing a tubular structures based on poly(ɛ-caprolactone) / poly(glycerol-sebacic acid) biodegradable nanocomposite blends: suggested for applications in the nervous, vascular and renal tissue engineering

Cited by 12 publications

References 44 publications

Current status of nano‐vaccinology in veterinary medicine science

Current status of nano‐vaccinology in veterinary medicine science

Synthesis and Characterization of Bio-nanocomposites Based on Poly(Glycerol Itaconic acid) (PGIt) and Using Poly(ɛ- caprolactone) diol (PCL-diol) as Macro Crosslinkers containing Cloisite Na + to application in Tissue engineering

Healing Clays Structure and Functions

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