The parameters group of the distributed feedback (DFB) laser equivalent circuit model based on the single-mode rate equations is the key to precisely presenting DFB response characteristics, so a novel optimization solution based on the response surface methodology (RSM) is proposed to rapidly select the optimized parameters by the multi-objective algorithm. The RSM model is designed to match the DFB laser characteristics related to the direct-current and small-signal frequency response, and non-dominated sorting genetic algorithm-II (NSGA-II) attributes to elevating the RSM model optimizing to screen out an optimal set of parameters by Pareto sorting. To further verify the accuracy of the model, the resonant frequency (fr) and the threshold current (Ith) are considered the objective optimization variables to set the target values as 18 GHz and 11.5 mA. The single-objective and multi-objective optimization are analyzed and compared to each other, and the optimized results have shown good agreement with predicted values, such as lower Ith in the multi-objective optimization while close fr in both cases. It has been demonstrated that optimization makes it possible not only to exploit the potential of existing DFB lasers but also to provide guidance for the inverse design of laser.