Within the framework of blade aerodynamic design, the maximum aerodynamic efficiency, power production, and minimum thrust force are the targets to obtain. This paper describes an improved optimization framework for blade aerodynamic design under realistic conditions, while considering multiple design parameters. The relationship between the objective function and the design parameters, such as the chord length, maximum chord, and twist angle, were obtained by using the second-order response surface methodology (RSM). Moreover, the identified parameters were organized to optimize the aerodynamic design of the blades. Furthermore, the initial and optimized blade geometries were compared and showed that the performance of the optimized blade improved significantly. In fact, the efficiency was increased by approximately 10%, although its thrust was not varied. In addition, to demonstrate the improvement in the resulting optimized blades, the annual energy production (AEP) was estimated when installed in a specific regional location. The result showed a significant improvement when compared to the baseline blades. This result will be extended to a new perspective approach for a more robust optimal design of a wind turbine blade.