Cellular Materials and Topology Optimization use a structured distribution of material to achieve specific mechanical properties. The controlled distribution of material often leads to several advantages including the customization of the resulting mechanical properties; this can be achieved following these two approaches. In this work, a review of these two as approaches used with compliance purposes applied at flexure level is presented. The related literature is assessed with the aim of clarifying how they can be used in tailoring stiffness of flexure elements. Basic concepts needed to understand the fundamental process of each approach are presented. Further, tailoring stiffness is described as an evolutionary process used in compliance applications. Additionally, works that used these approaches to tailor stiffness of flexure elements are described and categorized. Finally, concluding remarks and recommendations to further extend the study of these two approaches in tailoring the stiffness of flexure elements are discussed.