2016
DOI: 10.1016/j.ijpharm.2016.05.040
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Design and optimization of novel paclitaxel-loaded folate-conjugated amphiphilic cyclodextrin nanoparticles

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Cited by 50 publications
(31 citation statements)
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“…The smallest particle size was obtained without the surfactant for all nanoparticle formulations. This is found to be in accordance with previous studies reported in the literature proving that amphiphilic CDs are able to form nanoparticles without the presence of surfactants [ 21 22 24 , 32 34 ] due to their favorable self-alignment properties at air–water or oil–water interface [ 35 ]. The mean particle size of amphiphilic CD nanoparticles increased linearly with concentration of surfactant.…”
Section: Resultssupporting
confidence: 93%
“…The smallest particle size was obtained without the surfactant for all nanoparticle formulations. This is found to be in accordance with previous studies reported in the literature proving that amphiphilic CDs are able to form nanoparticles without the presence of surfactants [ 21 22 24 , 32 34 ] due to their favorable self-alignment properties at air–water or oil–water interface [ 35 ]. The mean particle size of amphiphilic CD nanoparticles increased linearly with concentration of surfactant.…”
Section: Resultssupporting
confidence: 93%
“…shown that nanosystems loaded with placlitaxel enhance tumor cell sensitivity via folic acid targeting, increasing the cellular uptake of the drug. In this sense, cyclodextrin nanoparticles and liposomes decorated with folic acid and loaded with PTX significantly increased in vitro drug efficacy on ZR75-1 [6] and MCF-7 and MDA-MB-231 cells (FR-αpositive) respectively, decreasing IC50 values. In the case of liposomes the IC50 of folate decorated formulations were 2,2 and 11.5 times lower than nondecorated ones for MCF7 and MDA-MB-231 cells respectively.…”
Section: Introductionmentioning
confidence: 93%
“…Folic acid is one of the most promising ligands due to: (i) the overexpression of folate receptor-α (FR-α) in numerous kinds of tumors including ovarian, breast, kidneys, lung, uterus, and colon carcinomas; showing folic acid a high binding affinity for these receptors (Kd~10 10 M -1 ); (ii) its low immunogenicity, (iii) it is easy modify and (iv) its low cost [5,6]. This paper focuses on the use of folic acid decorated nanomedicines loaded with conventional anticancer drugs as targeted chemotherapy strategy in gynaecological cancers.…”
Section: Introductionmentioning
confidence: 99%
“…al. reported folic acid decorated amphiphilic β ‐CDs . Folic acid can complex with high affinity to the folate receptor, which is overexpressed on several cancer cells such as breast, ovary and lung .…”
Section: Amphiphilic Cds For Drug Deliverymentioning
confidence: 99%