Design and Pharmacodynamic Evaluation of Optimized Microporous Osmotic Tablets of Venlafaxine Hydrochloride

Abstract

Monica, et al.: Microporous Osmotic Tablets of Venlafaxine HydrochlorideMicroporous osmotic tablets were developed using controlled porosity membrane, which delivers drug in a controlled manner for prolonged period of time. The objective of the present investigation was to formulate and evaluate an oral osmotic drug delivery system for the antidepressant drug venlafaxine hydrochloride to achieve zero order release. Venlafaxine hydrochloride was selected as it has a short biological half-life and high aqueous solubility. Drug-excipient compatibility was studied using Fourier transform infrared spectroscopy. Core tablets were prepared by wet granulation method followed by coating. Sodium chloride and potassium chloride (1:1) were used as osmotic agents in the core tablet and polymers Eudragit RLPO and RSPO (1:1) were used for coating along with sorbitol (70% w/w) as pore formers. The tablets showed desired sustained release profile for 24 h. Optimization studies were performed to study the effect of concentration of osmotic agent and pore former on drug release (t 50% and t 90% ). From in vitro release studies, it was evident that drug release was independent of dissolution media, agitation intensity, but highly dependent on the concentration of pore forming agents, osmotic agent and weight gain of the tablet coating. Scanning electron microscopy confirmed the microporous structure of optimized batch. The optimized formulation gave desired once a day release of venlafaxine hydrochloride without using laser drilling technique, which would make it more patient compliant and cost effective.

Bran of cassava starch flour and bran of cassava flour as potential tablet excipients

“…(22,23) Venlafaxine hydrochloride was selected as model drug for this study due to its high aqueous solubility. (24) The other components employed in the formulations are commonly employed in the production of tablets. (4) The tablets of the three formulations produced with higher compression forces (160-200 MPa) resulted in tablets with a better appearance.…”

“…The values of disintegration time of a tablet are related to the processes of dissolution/absorption and, hence, to the bioavailability of the drug, while the hardness and friability of a tablet will define their physical stability. (24) Orsi VC, et al…”

Development and Evaluation of Self Micro-Emulsifying Formulation of Venlafaxine HCl with Improved Antidepressant Activity

“…The VEN content from the final solution was determined at 276 nm with a UV-spectrophotometer (UV 1700, Shimadzu) and drug content was calculated from a previously constructed standard curve in same solvent. 35 In vitro dissolution 7,36,37 In vitro dissolution efficiency of developed formulation was tested using USP dissolution apparatus II (VDA-8D4, Veego Instruments). Considering the conditions of stomach, 500 mL of 0.1 N HCl was used as dissolution media.…”