Porous Oral Drug Delivery System: Tablets

Singh, Samayveer; Verma, Ruchi; Kumar, Lalit

doi:10.1007/s11094-018-1859-5

Cited by 9 publications

(1 citation statement)

References 23 publications

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“…Among encapsulation approaches, loading into porous biopolymers has received significant attention due to their excellent material properties, including ultra‐low density, high surface area and porosity, tunable surface chemistry, biocompatibility, and biodegradability (Luo et al., 2020; Manzocco et al., 2021; Sampath et al., 2016). Loading BCs into the porous structure of biopolymers decreases compounds’ particle size, increases their solubilization and chemical stability, and, consequently, improves their bioaccessibility and bioavailability (Ahmad & Gani, 2021; Jiang et al., 2014; Singh et al., 2018; Ubeyitogullari & Ciftci, 2016b). These porous biopolymers can be used to encapsulate both hydrophilic and hydrophobic BCs, and provide a relatively high encapsulation efficiency and capacity.…”

Section: Introductionmentioning

confidence: 99%

Polysaccharide‐based porous biopolymers for enhanced bioaccessibility and bioavailability of bioactive food compounds: Challenges, advances, and opportunities

Ubeyitogullari

Ahmadzadeh

Kandhola

et al. 2022

Comp Rev Food Sci Food Safe

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Bioactive food compounds, such as lycopene, curcumin, phytosterols, and resveratrol, have received great attention due to their potential health benefits.However, these bioactive compounds (BCs) have poor chemical stability during processing and low bioavailability after consumption. Several delivery systems have been proposed for enhancing their stability and bioavailability. Among these methods, porous biopolymers have emerged as alternative encapsulation materials, as they have superior properties like high surface area, porosity, and tunable surface chemistry to entrap BCs. This reduces the crystallinity (especially for the lipophilic ones) and particle size, and in turn, increases solubilization and bioavailability. Also, loading BCs into the porous matrix can protect them against environmental stresses such as light, heat, oxygen, and pH. This review introduces polysaccharide-based porous biopolymers for improving the bioaccessibility/bioavailability of bioactive food compounds and discusses their recent applications in the food industry. First, bioaccessibility and bioavailability are described with a special emphasis on the factors affecting them. Then, porous biopolymer fabrication methods, including supercritical carbon dioxide

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