Design and Physicochemical Evaluation of Nanostructured Lipid Carrier Encapsulated Zingiber Zerumbet Oil by D-Optimal Mixture Design

Rosli, Nur Ayshah; Hasham, Rosnani; Aziz, Azila Abdul

doi:10.11113/jt.v80.11268

Cited by 11 publications

(7 citation statements)

References 37 publications

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“…Orange and thyme oil adsorbed in halloysite or montmorillonite clay and then encapsulated in a polyethylene/polyamide/polyethylene multilayer film prolongated aroma release [55]. Encapsulation of black pepper (Piper nigrum L.) EO into sodium alginate and gelatin by complex coacervation avoids the loss of the main volatile from EOs preserved (80% of their original content) [56].…”

Section: Encapsulation Of Eosmentioning

confidence: 99%

Encapsulation of Essential Oils and Their Use in Food Applications

Shaaban¹,

Farouk²

2022

Biochemistry

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Due to the modern lifestyle and consumers’ interests, demands toward healthy foods and nutraceuticals were increased, among them essential oils (EOs) characterized by different biological activities. However, the use of EOs in foods and pharmaceuticals may be limited due to the hydrophobicity nature in addition to the instability and cause of degradation upon exposure to environmental conditions, e.g., oxygen, temperature, and light. Therefore, encapsulation in various colloidal systems such as microcapsules, nanospheres, nanoemulsions, liposomes, and molecular inclusion complexes, seem to be the solution for such issues. New trends in food packaging have also been focused on exploiting capsulated bioactive EOs constituents for extending foods’ shelf life due to their potent antimicrobial agents and the great activity against pathological bacteria. Micro and nanoencapsulation of EOs may affect their biological activities based on the technique used. In the current chapter, different subjects have been discussed, like techniques used for the encapsulation of EOs, potential applications in food, and their behaviors/trends after encapsulation.

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Section: Encapsulation Of Eosmentioning

confidence: 99%

Encapsulation of Essential Oils and Their Use in Food Applications

Shaaban¹,

Farouk²

2022

Biochemistry

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“…High shear homogenization followed by ultrasonication technique, [23][24][25][26] was used for PD-loaded NLC development. In this technique, two phases (lipid and aqueous surfactant solution phase) were prepared independently.…”

Section: Preparation Of Nlcsmentioning

confidence: 99%

Development and Characterization of Paliperidone Loaded Nanostructured Lipid Carrier

Dash¹,

Patra²,

Acharjya³

et al. 2022

Ind. J. Pharm. Edu. Res

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Background: Paliperidone is indicated for the treatment of schizophrenia. It has an absolute oral bioavailability of about 28% as it is poorly soluble in water and also undergoes hepatic first-pass metabolism. Objectives: The purpose of the present study is to improve the solubility, in vitro bioavailability of paliperidone by formulating nanostructured lipid carrier (NLC). Materials and Methods: High shear homogenization followed by the ultrasonication technique was used for the preparation of NLCs loaded with Paliperidone, and were prepared by varying weight of solid and liquid lipid in different ratios. Lyophilization of the selected NLC was carried out to further improve its stability. Results: Glyceryl monostearate, Linoleic acid, and Tween 80 to Tween 20 (2:1) were selected as solid lipid, liquid lipid, and surfactant correspondingly for the development of NLC. NLC formulation F5 was selected as the best formulation as it exhibited lowest particle size, PDI with stable zeta potential and drug release for 12 hr. Selected NLC F5 was further lyophilized to improve the stability using different cryoprotectants vis-à-vis sucrose, sorbitol and aerosol. Lyophilized NLC showed a slight increase in particle size. DSC and P-XRD study revealed molecular dispersion of paliperidone in lipid matrix. Conclusion: Hence the approach of formulating lyophilized NLC for paliperidone has the potential of improving in-vitro bioavailability.

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“…The mixture was then stirred and dripped into the test object. Grid at 400 mesh dropped into 10 ml of uranyl acetate on the grid; then the remaining droplets were then cleaned again using filter paper and left for 30 min to make it dry before inserting it into the TEM tool for image capture [8].…”

Section: Characterization Of Vitamin E Acetatementioning

confidence: 99%

Development and Characterization of Compritol Ato® Base in Nanostructured Lipid Carriers Formulation With the Probe Sonication Method

2022

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Objective: Vitamin E acetate has antioxidant activity that can prevent premature aging of the skin, but it is highly lipophilic (log p±12.2) and potentially degraded. To overcome the permeability and stability problems, the vitamin E acetate needs to be developed in Nanostructured Lipid Carrier (NLC), a nano-delivery system based on solid lipid and liquid lipid that is stabilized by surfactants as a colloidal system. Methods: The formulation of vitamin E acetate into NLC was carried out using hot homogenization method and then sonicated using a probe sonicator. The materials used were vitamin E acetate 2%, Compritol® 2-6%, Myritol® 1%, and Plantacare® 1-3%. The results of the NLC were then characterized by measuring the particle size, zeta potential, polydispersity index, entrapment efficiency, and its morphology. Results: The results of characterization showed that NLC of vitamin E acetate has 280-375 nm particle size, the zeta potential was-23 mV to-28 mV, the polydispersity index was<0.5, the entrapment efficiency was 92-97%, and the morphological results was in the form of a spherical shape. Conclusion: The results show that the Nanosturctured Lipid Carriers of vitamin E acetate shows good results.

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Design and Physicochemical Evaluation of Nanostructured Lipid Carrier Encapsulated Zingiber Zerumbet Oil by D-Optimal Mixture Design

Cited by 11 publications

References 37 publications

Encapsulation of Essential Oils and Their Use in Food Applications

Encapsulation of Essential Oils and Their Use in Food Applications

Development and Characterization of Paliperidone Loaded Nanostructured Lipid Carrier

Development and Characterization of Compritol Ato® Base in Nanostructured Lipid Carriers Formulation With the Probe Sonication Method

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