Design and Preparation of New Multifunctional Hydrogels Based on Chitosan/Acrylic Polymers for Drug Delivery and Wound Dressing Applications

Abstract

The dynamic evolution of materials with medical applications, particularly for drug delivery and wound dressing applications, gives impetus to design new proposed materials, among which, hydrogels represent a promising, powerful tool. In this context, multifunctional hydrogels have been obtained from chemically modified chitosan and acrylic polymers as cross-linkers, followed by subsequent conjugation with arginine. The hydrogels were finely tuned considering the variation of the synthetic monomer and the preparation conditions. The advantage of using both natural and synthetic polymers allowed porous networks with superabsorbent behavior, associated with a non-Fickian swelling mechanism. The in vitro release profiles for ibuprofen and the corresponding kinetics were studied, and the results revealed a swelling-controlled release. The biodegradability studies in the presence of lysozyme, along with the hemostatic evaluation and the induced fibroblast and stem cell proliferation, have shown that the prepared hydrogels exhibit characteristics that make them suitable for local drug delivery and wound dressing.

Phytochemical Profile, Antioxidant Activity, and Cytotoxicity Assessment of Tagetes erecta L. Flowers

“…Consequently, color development can serve as an indicator of viable cells [ 52 , 53 ]. The cytotoxicity assessment was performed by the evaluation of cell viability in the presence of the investigated samples, using a direct contact MTT assay, which was carried out according to the protocols in the existing literature, as well as according to the recommendations of ISO 10993-5 [ 54 , 55 ]. The absorbance of the obtained solutions was measured at 570 nm, using isopropanol as blank.…”

Bioinspired Hydrogels as Platforms for Life-Science Applications: Challenges and Opportunities

“…Chitosan (CS) and chitin (CH) present in their composition D-glucosamine and N-acetyl-D-glucosamine, in form of acetylated amine groups in CH and as primary aliphatic amine groups in CS (Figure 9). They were used for many innovative biomimetic materials [29,39,42,52,66,67,96,121,122,132,[190][191][192][193][194][195][196][197] due to their unique properties, depending on source of polysaccharide (external shell or cell wall, soft wings, transparent layer for eyes of insects, etc.) as well as the location and living conditions of animals/insects [198].…”

A Comprehensive Review on Ulvan Based Hydrogel and Its Biomedical Applications

“…111) However, there are some controlling factors like swelling force, mechanical strength, diffusion release (matrix or reservoir system), and viscosity that need to be considered to release the drug from the matrix. 3,[112][113][114][115] Ulvan has been modified with lysozyme that has cationic charged. The complex formation results in stable nanoparticles and increasing antibacterial activity.…”