Design and Simulation of MEMS Biosensor for the Detection of Tuberculosis

Murthy, K. Srikanta; Prasad, G. R. K.; Saikiran, N. L. N. V.; Manoj, T. V. S.

doi:10.17485/ijst/2016/v9i31/90638

Cited by 11 publications

(4 citation statements)

References 4 publications

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“…For bio-recognition, the cantilever surface is made bio-sensitive by applying a sensor layer on it [11]. The structure of micro cantilever which is based on micromechanical and electromechanical sensor has fixed on one end and other end of it is free for displacement [12,13]. The displacement generated on the sensitive surface of cantilever due to the collaboration of antigen antibody that means biochemical reaction.…”

Section: IImentioning

confidence: 99%

Comparative Study of Cantilever Biosensor for Detection of Tuberculosis

Thorat,

Jadhav,

Bedke

2024

IJRASET

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Now everywhere in the world sensors are used to solve daily human problem. In the medical field sensors are used to diagnose various diseases. In this article for detection of tuberculosis, micro cantilever biosensor has been design and simulate. Rectangular shape cantilever biosensors with silicon, poly-silicon and aluminium material were designed and analysed the displacement. The displacements of this biosensor are compared with the other available models. The MEMS based micro cantilever biosensor were design in COMSOL Multiphysics. 10N to 100N load force are applied on the surface of cantilever for deliberate the interaction of antigen antibody. Stress generated on the surface of cantilever when antigen antibody binds together and it get deflects. This deflection is measured for 10N to 100N load force which is compare with other modules. The displacement generated by cantilever was 1.71 x 1028 µm for 100N force which is higher than all the other models, thus the proposed cantilever model is the best model for detection of tuberculosis

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Section: IImentioning

confidence: 99%

Comparative Study of Cantilever Biosensor for Detection of Tuberculosis

Thorat,

Jadhav,

Bedke

2024

IJRASET

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“…The vibrational frequency or variations in cantilever bending can be identify by micro cantilever sensor. The structure of micromechanical and electromechanical sensor associated by micro cantilever sensor [14,15]. With the collaboration of antigen-antibodies, the stress generated on sensitive aspect of cantilever, which generated displacement on one side of cantilever, as one edge of it is fixed and other edge is free for displacement.…”

Section: Bio-mems Cantilever Sensormentioning

confidence: 99%

Automated Detection of Tuberculosis Based on Cantilever Biosensor

Thorat¹,

Jadhav²

2023

Advances in Intelligent Systems Research

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Mycobacterium Tuberculosis is one of the most hazardous disease. Universally millions of people are suffering from this dangerous disease. Number of detection techniques are available, but due to its complex structure this infectious disease not get diagnose easily and within time. To prevent spreading the bacteria and to stop mortality there is a huge requirement to build an automated and easy technique which can detect tuberculosis at a developing phase. The purpose of the article is to design and simulate the cantilever biosensor for detection of tuberculosis. Micro cantilever biosensor are designed with cylindrical and rectangular shape with silicon substrate. The cantilever surface is coated with antibodies and when patient sample is placed on it, the antigen-antibody gets binds together. When targeted antigen-antibody binds together stress generated and it forms deflection. The displacement achieved by Cylindrical-shape was 2.06 × 10 6 µm and rectangular-shape was 1.2 × 10 26 µm for 100N load force correlates to 28.228 × 10 -24 kg weight of antigen. From both the model maximum displacement were recorded and considered the rectangular-shape model as the leading model for tuberculosis detection.

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“…Variations in Cantilever bending or vibrational frequency can be identify by micro cantilever which act as a sensor. Micro cantilever sensors accompanied the structure of micromechanical and electromechanical sensors (14,15). Its, one side is fixed and the other side is free for displacement.…”

Section: Micro Cantilever Biosensormentioning

confidence: 99%

Design and Exploration of Micro Cantilever Biosensor for Detection of Tuberculosis

Thorat¹,

Jadhav²

2022

ECS Trans.

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According to the WHO, health is a circumstances of personal resources. There is a necessity to prevent health related issues by diagnosing the disease within time. Number of hazardous diseases are there which are not able to catch within time. Globally from top ten diseases, one of the leading cause of death is tuberculosis. Due to the complicated structure, diagnose the bacteria of tuberculosis is very tedious job. Its an airborne disease. So there is a huge requirement to build a technique which can detect tuberculosis easily and at an early stage. The purpose of the paper is to study, design, and simulate the cantilever biosensor for quick detection of tuberculosis. Micro cantilever biosensor are designed with different dimensions and shapes. The surface of micro cantilever biosensor are prepared with various materials and are coated with antibodies. The sample of patient is placed on to the cantilever, if sample is infected with tuberculosis then antibodies get binds with antigens and it generate stress on the surface and it delivers displacement. Displacement of various designs of micro cantilever were analyzed and maximum displacement were recorded. Rectangle shape with gold material of micro cantilever biosensor achieved maximum displacement as 1.71 x 1028 µm for a load of 100N.

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Design and Simulation of MEMS Biosensor for the Detection of Tuberculosis

Cited by 11 publications

References 4 publications

Comparative Study of Cantilever Biosensor for Detection of Tuberculosis

Comparative Study of Cantilever Biosensor for Detection of Tuberculosis

Automated Detection of Tuberculosis Based on Cantilever Biosensor

Design and Exploration of Micro Cantilever Biosensor for Detection of Tuberculosis

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