Continuous formation of new businesses, start-ups, which could establish themselves on the market and be successful, should be supported in all economic areas, and the area of agriculture is no exception. Thus the main aim of this paper is to formulate a recommendation for educational institutions which prepare future generations, among others, to establish start-ups in agriculture that reflect fundamental success factors. The data were acquired with the aid of structured interviews (n = 6), which were carried out in electronic form. The respondents agreed that they considered the greatest obstacle, and at the same time challenge, to be the entry into the unknown, and that fear of failure in the context of an enterprise in the area of agriculture, food and nutrition has arrived only in the last few years, when loans, employees and obligations are on the rise.