Design and stereoselective synthesis of novel isosteviol-fused pyrazolines and pyrazoles as potential anticancer agents

Recent Reports on Pyrazole-Based Bioactive Compounds as Candidate for Anticancer Agents

“…Thirty derivatives of pyrazole and pyrazoline bearing isosteviol moiety (17a-17ad) were synthesized by Zhu et al [25]. The cytotoxic activities were evaluated in vitro against four human cancer cell [26].…”

Synthesis and pharmacological evaluation of some new fluorine containing hydroxypyrazolines as potential anticancer and antioxidant agents

“…Pyrazolines are used as anticancer [18,19], antioxidant [20], antitumor [21], anti-inflammatory [22], trypanocidal [23], MAO-B inhibitors [24], agonist of cannabinoid receptors [25] and antidepressant agents [26]. Therefore, the pyrazoline motif makes up the core structure of numerous biologically active compounds.…”

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“…Some of the compound showed good activity against COX-2. The in vitro cytotoxic activity against four human tumor cell lines of isosteviol derivatives containing pyrazoline heterocyclic fragments (4d) were evaluated by S.-L. Zhu et al 57 . It was revealed that introduction of pyrazoline heterocyclic fragments to isosteviol were beneficial to the cytotoxic activities.…”