Recent Reports on Pyrazole-Based Bioactive Compounds as Candidate for Anticancer Agents

Abstract

Pyrazole is a five-membered heterocyclic compound containing two nitrogen atoms. Due to its biological significance, design of novel pyrazole derivatives has become an interesting research area. We report the current progress in the development of anticancer agents containing pyrazole ring covering the time span of the past few years (2013)(2014)(2015)(2016). The presence of this nucleus is accompanied with some side chains, functional groups, or in combination with other nucleus such as thiazole, thiourea, glucosamine, naphthalimide, and benzofuran. Several biologically active pyrazoles synthesized by numerous researchers across the world are summarized in this paper.

Synthesis of some novel N5‐sulfonylated and N1‐alkyated pyrazole derivatives and their antimicrobial activity in conjunction with molecular docking study

“…Numerous 5‐aminopyrazole derivatives occupy a key place in medicinal, pharmaceutical, and agrochemical industry such as antibacterial, antifungal, antileishmanial, anticancer, antidepressant activity, and anti‐inflammatory . Also, they considered as noncompetitive GABA antagonists and insecticides, potent human A 2 B adenosine receptor antagonist, and anti‐tobacco mosaic virus activity .…”

In Vitro Cytotoxic Anticancer Potential of Bioactive Fraction Isolated From Indonesian Tidal Sponge Calthropella Sp.

“…Those isolated compounds have been reported to have a high anticancer activity [13][14][15]. In regard to mechanism of action, several recent studies reported that alkaloids have the ability to promote apoptosis through inducing DNA damage [16][17][18]. Other isolated compounds can also be expected to contribute to the anticancer activity possessed by marine sponge Calthropella sp.…”

Recent developments in synthetic chemistry and biological activities of pyrazole derivatives

“…[3][4][5] Amongst heterocyclic compounds, nitrogen-containing heterocycles are extensively found as a core framework in a huge library of heterocycles and show several employments in natural science and other areas of science. 6 Additionally, nitrogen-containing heterocycles have striking structural features and they are widely observed in natural products, for instance, vitamins, hormones and alkaloids. 7,8 Pyrazole 1 is known to be one of the most potential families of nitrogen-containing compounds.…”

“…Pyrazole derivatives exhibit a broad spectrum of biological profiles, for instance, anti-tubercular, 9 anti-AIDS, 10 anti-malarial, 8 * For correspondence anti-microbial, 11 antitumor, 12,13 anticancer 14 and antifungal. 6 In addition, pyrazoles have also been found as promising anti-hyperglycemic, 15 anti-depressant, 16 anti-convulsant, 17 anti-pyretic, 18 anti-anxiety 19,20 and insecticidal agents. 21 Bipyrazole shows diuretic, cytotoxic and cardiovascular efficacy.…”