Design and synthesis of amino acid derivatives containing hydantoin and thiazolidine moieties

Kotha, Sambasivarao; Gaikwad, Vidyasagar

doi:10.1007/s12039-022-02053-1

Cited by 2 publications

(2 citation statements)

References 38 publications

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“…[21] Recently, Kotha and Gaikwad reported hydantoin and thaizolidine containing spiro amino acids. [22] They also reported tetrahydro-β-carboline by using ethyl acetamidomalonate. [23] Additionally, constrained amino acids are prepared by using ethyl acetamidomalonate followed by RCM.…”

Section: Introductionmentioning

confidence: 99%

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Design and Synthesis of Amino Acid Derivatives via Diethyl Acetadimalonate and Late‐Stage Modification by Chemical Methods

2022

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We report various unusual amino acid derivatives containing heterocycles and heteroatoms (S, O, N) via diethyl acetadimalonate as a glycine equivalent and carried out further chemical transformations to modify these unusual amino acid derivatives. Sulfur‐containing halo and alkene derivatives are prepared, and these substrates are further modified by Suzuki‐Miyaura cross‐coupling reaction, cross metathesis sequence and selective formation of sulfoxide and sulfone derivatives. We also report oxazole‐containing amino acid derivative by using TosMIC.

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Section: Introductionmentioning

confidence: 99%

“…Thiazolidine is useful in designing broad spectrum of protein targets such as cox‐2 and histone deacetylase [21] . Recently, Kotha and Gaikwad reported hydantoin and thaizolidine containing spiro amino acids [22] . They also reported tetrahydro‐β‐carboline by using ethyl acetamidomalonate [23] .…”

Section: Introductionmentioning

confidence: 99%

Design and Synthesis of Amino Acid Derivatives via Diethyl Acetadimalonate and Late‐Stage Modification by Chemical Methods

2022

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Design of Synthetic Strategies towards Sulfur Containing Scaffolds

Kotha,

Khedkar

2024

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The utilization of sulfur heterocycles in organic synthesis has attracted significant attention due to their wide-ranging applications. This review showcases the syntheses of diverse sulfur heterocycles embedded with amino acid derivatives, polycycles, spirocycles, cyclophanes, and other complex scaffolds. The reported methods extend beyond compound synthesis and highlight the use of different sulfur reagents for constructing sulfur heterocycles. This Review also discusses the utility of a variety of sulfur-containing starting materials for the generation of complex target molecules.1 Introduction2 Potassium Thioacetate3 Thiazolidine-2,4-dione4 Rhodanines5 Sodium Sulfide6 Thiotetronic Acid7 Thiadiazoles8 Thiophene9 Rongalite10 Sulfur Dioxide11 Divinyl Sulfone12 Sulfur Heterocycles Based on Boronic Acids13 Miscellaneous14 Summary

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Design and synthesis of amino acid derivatives containing hydantoin and thiazolidine moieties

Cited by 2 publications

References 38 publications

Design and Synthesis of Amino Acid Derivatives via Diethyl Acetadimalonate and Late‐Stage Modification by Chemical Methods

Design and Synthesis of Amino Acid Derivatives via Diethyl Acetadimalonate and Late‐Stage Modification by Chemical Methods

Design of Synthetic Strategies towards Sulfur Containing Scaffolds

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