Design and Synthesis of an Aromatic-steroid Derivative

Figueroa‐Valverde, Lauro; Cedillo, Francisco Díaz; Elodia, García-Cervera; Gómez, E. Pool; Marcela, Rosas-Nexticapa; María, López-Ramos; May-Gil, Ivan

doi:10.13005/ojc/290209

Cited by 3 publications

(1 citation statement)

References 15 publications

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“…A review of the literature in this area turned up several publications on the antibacterial action of N -Mannich bases. The combination of Pregnenolone and Carbamazepine exhibits reduced efficacy against S. aureus and E. coli [ 10 ]. Furthermore, sulphonamide is widely recognized for its antibacterial [ [11] , [12] , [13] ], anti-tubercular [ 14 ], anti-inflammatory [ 15 ], and carbonic inhibitory [ 16 ] properties.…”

Section: Introductionmentioning

confidence: 99%

Design, synthesis, and molecular docking of new phenothiazine incorporated N-Mannich bases as promising antimicrobial agents

Abdula,

Qarah,

Alatawi

et al. 2024

Heliyon

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Section: Introductionmentioning

confidence: 99%

Design, synthesis, and molecular docking of new phenothiazine incorporated N-Mannich bases as promising antimicrobial agents

Abdula,

Qarah,

Alatawi

et al. 2024

Heliyon

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Retracted: Design and synthesis of a bismethylsulfanyl‐steroid‐azetyl butanol derivative from 2‐nitroestradiol

Figueroa‐Valverde

Francisco

María

et al. 2020

Journal of Heterocyclic Chem

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Several studies for the synthesis of polycyclic derivatives have been reported; however, there is little information on the preparation of steroid‐polycyclic derivatives. In this way, the aim of this study was to synthesize a bismethylsulfanyl‐steroid‐azetyl butanol derivative (compound 10) from 2‐nitroestrone. The chemical structure was evaluated through both 1H NMR and 13C NMR or spectroscopic analysis. The results showed a good yielding from 10. It is noteworthy that the reagents used in this investigation are not expensive and do not require special conditions for handling.

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Evaluation of activity exerted by a steroid derivative on injury by ischaemia/reperfusion

Figueroa‐Valverde¹,

DÃaz-Cedillo²,

Marcela³

et al. 2014

Afr. J. Pharm. Pharmacol.

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There are reports which indicate that some steroid derivatives have activity atcardiovascular level; nevertheless, there is scarce information about the effects exerted by the progesterone derivatives on cardiac injury caused by ischemia/reperfusion. In this study, a new steroid (progesterone derivative) was synthetized with the objective of evaluating its activity on ischemia/reperfusion injury. The Langendorff technique was used to evaluate the effect of progesterone derivative on ischemia/reperfusion injury. Additionally, molecular mechanism involved in the activity exerted by the progesterone derivative on perfusion pressure and coronary resistance was evaluated by measuring left ventricular pressure in absence or presence of following compounds; mifepristone, prazosin, metoprolol, indomethacin and nifedipine. The results showed that the progesterone derivative reduces infarct size compared with control. Other results showed that the progesterone derivative significantly increase (p = 0.05) the perfusion pressure and coronary resistance in isolated heart. Other data indicate that the progesterone derivative increase left ventricular pressure in a dose-dependent manner (0.001 to 100 nM); however, this phenomenon was significantly inhibited by nifedipine at a dose of 1 nM (p = 0.05). In conclusion, these data suggest that progesterone derivative exert acardioprotective effect via the calcium channels activation and consequently induces changes in the left ventricular pressure levels. This phenomenon results in decrease of myocardial necrosis after ischemia and reperfusion.

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Design and Synthesis of an Aromatic-steroid Derivative

Cited by 3 publications

References 15 publications

Design, synthesis, and molecular docking of new phenothiazine incorporated N-Mannich bases as promising antimicrobial agents

Design, synthesis, and molecular docking of new phenothiazine incorporated N-Mannich bases as promising antimicrobial agents

Retracted: Design and synthesis of a bismethylsulfanyl‐steroid‐azetyl butanol derivative from 2‐nitroestradiol

Evaluation of activity exerted by a steroid derivative on injury by ischaemia/reperfusion

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