2022
DOI: 10.1016/j.ejmech.2021.114021
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Design and synthesis of ciprofloxacin-sulfonamide hybrids to manipulate ciprofloxacin pharmacological qualities: Potency and side effects

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Cited by 33 publications
(14 citation statements)
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“…The second target is topoisomerase IV, accounted for the decatenation of the linked daughter chromosomes at the terminal stages of DNA replication. Quinolone drugs bind to the complex formed between DNA and the topoisomerase enzyme, forming a three-component complex, which inhibits bacterial cell growth. , …”
Section: Resultsmentioning
confidence: 99%
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“…The second target is topoisomerase IV, accounted for the decatenation of the linked daughter chromosomes at the terminal stages of DNA replication. Quinolone drugs bind to the complex formed between DNA and the topoisomerase enzyme, forming a three-component complex, which inhibits bacterial cell growth. , …”
Section: Resultsmentioning
confidence: 99%
“…Quinolone drugs bind to the complex formed between DNA and the topoisomerase enzyme, forming a three-component complex, which inhibits bacterial cell growth. 23,24 To compare the enzyme inhibitory properties of the most active antimicrobial agents (1−3, 5, 6, 10, and 11) with parental quinolones, their impact on S. aureus DNA gyrase and topoisomerase IV was evaluated (Table 4 and Figures 4 and 5). The amide 5 inhibited DNA supercoiling by gyrase and topo IV, with IC 50 values of the same order of activity as the references (3.2 and 2.7 μg/mL, respectively), which suggests a related mechanism of action.…”
Section: Biofilm Eradication Activitymentioning
confidence: 99%
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“…Nine standard strains were tested: Enterococcus faecalis ATCC19433, Staphylococcus aureus Newman, Klebsiella pneumoniae ATCC13883, Methicillin-resistant Staphylococcus aureus (MRSA USA300), Pseudomonas aeruginosa PAO1, Acinetobacter baumannii AB5075, Escherichia coli ATCC87, Enterobacter cloacae , and Salmonella typhi ATCC35664 [ 53 , 54 , 55 ].…”
Section: Methodsmentioning
confidence: 99%