Design and synthesis of new cationic water‐soluble pyrene containing dendrons for DNA sensory applications

Abstract

A series of new water‐soluble cationic pyrene‐dendron derivatives, G1, G2, and G3, was successfully synthesized and characterized. These new dendrons were designed with the quaternized amino moieties at the periphery of the dendrons for DNA detection and functionalized with pyrene as a fluorescent probe. The electrostatic interactions between the plasmid DNA (pDNA) and cationic charged dendrons in an aqueous solution resulted in a change in the photophysical properties of pyrene, which could be shown in the UV‐vis and fluorescence spectra. Pyrene dendrons showed a high and rapid fluorescence response upon the addition of pDNA, which was strongly dependent on the size and hydrophobicity of the dendrons. © 2011 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem, 2012

Single-Component Physical Hydrogels of Dendritic Molecules

“…Strong CD (circular dichroism) values were observed for the gels, contrarily to the solution, indicating that the chirality could be observed only in the gel [46]. A series of dendrons bearing a pyrene at the core and 2 to 8 ammonium terminal functions was first synthesized for DNA sensory applications [47]. The smallest dendrons A series of dendrons bearing a pyrene at the core and 2 to 8 ammonium terminal functions was first synthesized for DNA sensory applications [47].…”

“…A series of dendrons bearing a pyrene at the core and 2 to 8 ammonium terminal functions was first synthesized for DNA sensory applications [47]. The smallest dendrons A series of dendrons bearing a pyrene at the core and 2 to 8 ammonium terminal functions was first synthesized for DNA sensory applications [47]. The smallest dendrons of the series, such as 17-G1 (Figure 13) were then used to obtain pH-responsive hydrogels.…”

Solvent‐free polymerization of citric acid and hexamethylenediamine for novel carboxylated polyamides

“…The new polymers can be used as a novel type of so‐called polychelatogens (soluble polymers as metal chelators)17–22 and detergent builders (water‐softeners) 23–25. This study provides a new route to incorporation of a renewable natural material into new ionic polymers 21, 26–28…”

pH-Responsive and pyrene based electrospun nanofibers for DNA adsorption and detection

“…20 In the past decades, several pyrene-based DNA sensors have been developed. [21][22][23] For example, we reported the cationic charged amino moiety at the periphery of the dendrons with functional pyrene as uorescent probe for DNA detection. 23 Most of these pyrenebased DNA sensors are still operated in solutions that limit their applications.…”

“…[21][22][23] For example, we reported the cationic charged amino moiety at the periphery of the dendrons with functional pyrene as uorescent probe for DNA detection. 23 Most of these pyrenebased DNA sensors are still operated in solutions that limit their applications. Recently, pyrene-labeled ES nanobers have been developed via physical doping or covalent attachment of pyrene to nanobers for TNT and metal ions detection.…”