Design and synthesis of novel quinazolinyl-bisspirooxindoles as potent anti-tubercular agents: an ultrasound-promoted methodology

Ultrasound-assisted ionic liquid-mediated green method for synthesis of 1,3-diphenylpyrazole-based spirooxindolopyrrolizidines, their anti-tubercular activity, molecular docking study and ADME predictions

“…20 Similar to this, spirooxindoles were considered to be chosen structural motifs for novel drug discovery because of their distinctive structural characteristics and attractive pharmacological profiles. 21 Stephen et al reported spirooxindolo-pyrrolidine, pyrrolizine and pyrrolo-thiazole hybrids with good in vitro anti-mycobacterial activity (Fig. 1, compound- S ).…”

Synthesis, Anti-mycobacterial activity, Molecular Docking and ADME analysis of spiroquinoxaline-1,2,4-oxadiazoles via [3+2] cycloaddition reaction under ultrasound irradiation

“…There is no literature on the synthesis of spiroquinoxaline-1,2,4oxadiazoles utilizing ultrasonic irradiation that we are aware of now. As a result, we disclose the use of ultrasound to help in the [3 + 2] cycloaddition process to make spiroquinoxaline-1,2,4-oxadiazoles as part of our ongoing study into green chemistry and bio-active spiroquinoxaline-1,2,4-oxadiazoles [28][29][30][31].…”