Design and Synthesis of Poly(ADP‐ribose)polymerase‐1 (PARP‐1) Inhibitors. Part 3. In vitro Evaluation of 1,3,4,5‐Tetrahydro‐benzo[c][1,6]‐ and [c][1,7]‐naphthyridin‐6‐ones.

Abstract

Fused pyridine derivativesFused pyridine derivatives R 0450Design and Synthesis of Poly(ADP-ribose)polymerase-1 (PARP-1) Inhibitors. Part In vitro Evaluation of 1,3,4,5-Tetrahydro-benzo[c][1,6]-and [c][1,7]-naphthyri-din-6-ones. -Design, synthesis and in vitro activities of the title benzonaphthyridines (VIII) and (XV), resp., as well as corresponding aminoacylated products [cf. (IX)] as PARP-1 inhibitors are reported. -(FERRARIS*, D.; FICCO, R. P.; PAHUTSKI, T.; LAUTAR, S.; HUANG, S.; ZHANG, J.; KALISH, V.; Bioorg. Med. Chem. Lett. 13 (2003) 15, 2513-2518; Dep. Res., Guilford Pharm., Inc., Baltimore, MD 21224, USA; Eng.) -M. Schroeter 44-132 2003 Fused pyridine derivatives