2001
DOI: 10.1002/jhet.5570380121
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Design and synthesis of some new pyranoxanthenones with cytotoxic activity

Abstract: As part of a research program directed towards the design and synthesis of pyranoxanthones structurally related to acronycine, we present here the synthesis and cytotoxic activity of the pyranoxanthones 3 and 4 (X= H, Br; R= H, OMe; R'= H, Ac). Some of these compounds inhibit L1210 cell proliferation.

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Cited by 8 publications
(2 citation statements)
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“…In general, the angular analogues, which possess a structural similarity with acronycine ( 3 ), have been shown to induce a partial accumulation of cells in the G2/M phase of the cell cycle. On the other hand, the linear analogues induced a partial accumulation of cells in the G1 phase of the cell cycle (36). Results presented herein clearly show that treatment of K‐562 cells with compound 5 , a linear pyran‐fused xanthone, caused a concentration‐ and time‐dependent delayed progression of the K‐562 cells through the S‐phase of the cell cycle, resulting in an S‐phase cell cycle arrest with an almost complete disappearance of cells in G2/M.…”
Section: Discussionmentioning
confidence: 99%
“…In general, the angular analogues, which possess a structural similarity with acronycine ( 3 ), have been shown to induce a partial accumulation of cells in the G2/M phase of the cell cycle. On the other hand, the linear analogues induced a partial accumulation of cells in the G1 phase of the cell cycle (36). Results presented herein clearly show that treatment of K‐562 cells with compound 5 , a linear pyran‐fused xanthone, caused a concentration‐ and time‐dependent delayed progression of the K‐562 cells through the S‐phase of the cell cycle, resulting in an S‐phase cell cycle arrest with an almost complete disappearance of cells in G2/M.…”
Section: Discussionmentioning
confidence: 99%
“…We have been involved in the design, synthesis, and cytotoxic activity evaluation of a number of linear and angular pyranoxanthenone derivatives [11, 12] possessing structural similarity with the pyranoacridone alkaloid acronycine (Fig. 1), which has shown promising antitumor properties on several murine solid tumor models [13].…”
Section: Introductionmentioning
confidence: 99%