Design and Synthesis of Two Bicyclo[3.3.1]nonane-steroid Derivatives

Figueroa‐Valverde, Lauro; Garcimarero, Alejandra; Garcia, R.; Díaz, Francisco; Rosas, Marcela; Mateu, Virginia; López, M.; Hau, Lenin; López, Tomás Quintana; Camacho, Abelardo; Borges, Yaritza

doi:10.19261/cjm.2019.657

Cited by 1 publication

(2 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Analyzing these data, the aim of this investigation was to evaluate the biological activity exerted by a Fluoro-2,4dioxaspiro[bicyclo[3.3.1]indene derivative (Figure 1) against using an ischemia/reperfusion model (Figure 1). In this way, all chemical properties, such as the 1 H and 13 C NMR spectra for the Fluoride-ether derivative, have already been reported [14]. The results (Figure 2) showed that the Fluoro-2,4dioxaspiro[bicyclo [3.3.1]indene derivative decrease the infarct area in a dose-dependent manner compared with conditions control (Krebs-Henseleit solution).…”

Section: Biological Activitymentioning

confidence: 60%

“…The compound 8-fluoro-1',3'-dihydro-2,4-dioxaspiro[bicyclo[3.3.1]nonane-3,2'indene]--1(9),5,7-triene (Fluoro-2,4dioxaspiro[bicyclo[3.3.1]indene derivative, Figure 1) was prepared using a previously method [14]. In this way, all chemical properties, such as the 1 H and 13 C NMR spectra for the Fluoride-ether derivative, have already been reported.…”

Section: Generalitiesmentioning

confidence: 99%

See 1 more Smart Citation

Activity Exerted by Fluoro-2,4-Dioxaspiro[Bicyclo[3.3.1]Indene Derivative Against Ischemia/Reperfusion Injury

2020

Lett Appl NanoBioSci

View full text Add to dashboard Cite

Several drugs for the treatment of heart failure; however, some of these drugs can produce some secondary effects such as arrhythmias and hypercalcemia and others. The aim of this investigation was to evaluate the biological activity of a Fluoro-2,4dioxaspiro[bicyclo[3.3.1]indene derivative against both infarct area and left ventricular pressure. The effect exerted of a Fluoro-2,4dioxaspiro[bicyclo[3.3.1]indene derivative against both infarct area and left ventricular pressure was evaluated in an ischemia/reperfusion model using indomethacin and ramatroban as a control. Furthermore, a theoretical study was carried out to determine the interaction of Fluoro-2,4dioxaspiro[bicyclo[3.3.1]indene derivative with COX-1, COX-2, and thromboxane A2 using the 5u6x, 3ntg, and 6iiu proteins as controls. The results showed that Fluoro-2,4dioxaspiro[bicyclo[3.3.1]indene derivative decrease the infarct and left ventricular pressure; however, this effect was inhibited in the presence of ramatroban. In addition, other data indicated that Fluoro-2,4dioxaspiro[bicyclo[3.3.1]indene derivative could interact with both COX-2 and thromboxane A2 protein surface. All these data indicate that the biological activity of Fluoro-2,4dioxaspiro[bicyclo[3.3.1]indene derivative against infarct area and left ventricular pressure was via both COX-2 and thromboxane A2 inhibition. Therefore, this compound could be s candidate for the treatment of heart failure.

show abstract

Section: Biological Activitymentioning

confidence: 60%

Section: Generalitiesmentioning

confidence: 99%