A new approach in the development of aircraft and aerospace industry is geared toward increasing use of electric systems. An electromechanical (EM) piezoelectric-based system is one of the potential technologies that can produce a compactable system with a fast response and a high power density. However, piezoelectric materials generate a small strain, of around 0.1–0.2% of the original actuator length, limiting their potential in large-scale applications. This paper reviews the potential amplification mechanisms for piezoelectric-based systems targeting aerospace applications. The concepts, structural designs, and operation conditions of each method are summarized and compared. This review aims to provide a good understanding of piezoelectric-based systems toward selecting suitable designs for potential aerospace applications and an outlook for novel designs in the near future.