Design and Translation of Nanolayer Assembly Processes: Electrochemical Energy to Programmable Pharmacies

Hyder, M.N.; Shah, Naseem; Hammond, Paula T.

doi:10.1002/9783527646746.ch17

Cited by 7 publications

(8 citation statements)

References 73 publications

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“…In addition, layerby-layer film formation is versatile and can be performed on many different surfaces such as textiles, walls, wood, glass, metal, and so forth. 163,164 With the advent of spray layer-bylayer assembly, 165 composites such as these could be rapidly manufactured on an industrial scale onto many substrates or even applied as paint. 9,[163][164][165][166] PANI is also a promising material for composites with high capacity inorganic materials that lack ionic and electronic conductivity.…”

Section: Panimentioning

confidence: 99%

“…163,164 With the advent of spray layer-bylayer assembly, 165 composites such as these could be rapidly manufactured on an industrial scale onto many substrates or even applied as paint. 9,[163][164][165][166] PANI is also a promising material for composites with high capacity inorganic materials that lack ionic and electronic conductivity. 23,167,168 Our group has recently combined PANI and vanadium pentoxide in a layer-by-layer electrode (Fig.…”

Section: Panimentioning

confidence: 99%

See 1 more Smart Citation

Recent advances in conjugated polymer energy storage

Mike

Lutkenhaus

2013

J Polym Sci B Polym Phys

190

152

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This review covers recent advances in conjugated polymers and their application in energy storage. Conjugated polymers are promising cost-effective, lightweight, and flexible electrode materials. The operating principles of conjugated polymers are presented within the framework of their potential for energy storage. Special focus is given to polyaniline electrodes. Recent advances are reviewed including new methods of synthesis, nanostructuring, and assembly. Also, covered are applications that take full advantage of the mechanical properties of conjugated polymers and future applications of these novel materials.

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Section: Panimentioning

confidence: 99%

Section: Panimentioning

confidence: 99%

Recent advances in conjugated polymer energy storage

Mike

Lutkenhaus

2013

J Polym Sci B Polym Phys

190

152

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“…LbL assembly [6] is a highly controlled approach to iteratively deposit materials and functionalize the surface of virtually any substrate on the basis of complementary interactions, such as electrostatics. This method allows for tunable, nanoscale precision over system design, allowing for the construction of a customizable therapeutic delivery platform [5i, 7] . Recent work has demonstrated the potential for LbL nanoparticle systems to promote improved pharmacokinetics and biodistribution of the carrier and drug in vivo , [8] with the ability to modulate release of encapsulated therapeutics.…”

Section: Introductionmentioning

confidence: 99%

Osteotropic Therapy via Targeted Layer‐by‐Layer Nanoparticles

Morton

Shah

Quadir

et al. 2013

Adv Healthcare Materials

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Current treatment options for debilitating bone diseases such as osteosarcoma, osteoporosis, and bone metastatic cancer are suboptimal and have low efficacy. New treatment options for these pathologies require targeted therapy that maximizes exposure to the diseased tissue and minimizes off-target side effects. This work investigates an approach for generating functional and targeted drug carriers specifically for treating primary osteosarcoma, a disease in which recurrence is common and the cure rate has remained around 20%. Our approach utilizes the modularity of Layer-by-Layer (LbL) assembly to generate tissue-specific drug carriers for systemic administration. This is accomplished via surface modification of drug-loaded nanoparticles with an aqueous polyelectrolyte, poly(acrylic acid) (PAA), side-chain functionalized with alendronate, a potent clinically-used bisphosphonate. Nanoparticles coated with PAA-Alendronate are observed to bind and internalize rapidly in human osteosarcoma 143B cells. Encapsulation of doxorubicin, a front-line chemotherapeutic, in an LbL-targeted liposome demonstrates potent toxicity in vitro. Active targeting of 143B xenografts in NCR nude mice with the LbL-targeted doxorubicin liposomes promotes enhanced, prolonged tumor accumulation and significantly improved efficacy. This report represents a tunable approach towards the synthesis of drug carriers, in which LbL can enable surface modification of nanoparticles for tissue-specific targeting and treatment.

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“…The layer-by-layer (LbL) assembly technique has uniquely demonstrated the construction of thin films under benign aqueous conditions for controlled release of numerous therapeutics, including proteins, growth factors, peptides, and small molecules (20). This technique relies on numerous intermolecular interactions (e.g., electrostatic) for assembly and stability; thus, the use of high molecular weight polyelectrolytes can result in films that are extremely robust and capable of coating a variety of materials and substrate geometries.…”

mentioning

confidence: 99%

Multimonth controlled small molecule release from biodegradable thin films

Hsu

Park

Hagerman

et al. 2014

Proc. Natl. Acad. Sci. U.S.A.

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Long-term, localized delivery of small molecules from a biodegradable thin film is challenging owing to their low molecular weight and poor charge density. Accomplishing highly extended controlled release can facilitate high therapeutic levels in specific regions of the body while significantly reducing the toxicity to vital organs typically caused by systemic administration and decreasing the need for medical intervention because of its longlasting release. Also important is the ability to achieve high drug loadings in thin film coatings to allow incorporation of significant drug amounts on implant surfaces. Here we report a sustained release formulation for small molecules based on a soluble charged polymer-drug conjugate that is immobilized into nanoscale, conformal, layer-by-layer assembled films applicable to a variety of substrate surfaces. We measured a highly predictable sustained drug release from a polymer thin film coating of 0.5-2.7 μm that continued for more than 14 mo with physiologically relevant drug concentrations, providing an important drug delivery advance. We demonstrated this effect with a potent small molecule nonsteroidal anti-inflammatory drug, diclofenac, because this drug can be used to address chronic pain, osteoarthritis, and a range of other critical medical issues.NSAID | polyelectrolyte multilayers | polymer prodrug

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Design and Translation of Nanolayer Assembly Processes: Electrochemical Energy to Programmable Pharmacies

Cited by 7 publications

References 73 publications

Recent advances in conjugated polymer energy storage

Recent advances in conjugated polymer energy storage

Osteotropic Therapy via Targeted Layer‐by‐Layer Nanoparticles

Multimonth controlled small molecule release from biodegradable thin films

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