Design automation for continuous-flow microfluidic biochips: A comprehensive review

Liu, Genggeng; Huang, Hongbin; Chen, Zhisheng; Lin, Hongxing; Liu, Hui; Huang, Xing; Guo, Wenzhong

doi:10.1016/j.vlsi.2021.09.002

Cited by 20 publications

(7 citation statements)

References 96 publications

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“…The delivery system is intended to supply and/ or dose the test specimen to the sensing area of the biochip [ 66 ]. The delivery system can be very straightforward: for example, as mentioned in [ 67 ], the test specimen can be brought directly to the sensing area manually by a syringe (Fig.…”

Section: Delivery Systemmentioning

confidence: 99%

Device Processing Challenges for Miniaturized Sensing Systems Targeting Biological Fluids

Stoukatch

Dupont

Redouté

2022

Biomedical Materials & Devices

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This article presents a review of device processing technologies used in the fabrication of biomedical systems, and highlights the requirements of advanced manufacturing technology. We focus on biomedical systems that perform diagnostics of fluidic specimens, with analytes that are in the liquid phase. In the introduction, we define biomedical systems as well as their versatile applications and the essential current trends. The paper gives an overview of the most important biomolecules that typically must be detected or analyzed in several applications. The paper is structured as follows. First, the conventional architecture and construction of a biosensing system is introduced. We provide an overview of the most common biosensing methods that are currently used for the detection of biomolecules and its analysis. We present an overview of reported biochips, and explain the technology of biofunctionalization and detection principles, including their corresponding advantages and disadvantages. Next, we introduce microfluidics as a method for delivery of the specimen to the biochip sensing area. A special focus lies on material requirements and on manufacturing technology for fabricating microfluidic systems, both for niche and mass-scale production segments. We formulate requirements and constraints for integrating the biochips and microfluidic systems. The possible impacts of the conventional microassembly techniques and processing methods on the entire biomedical system and its specific parts are also described. On that basis, we explain the need for alternative microassembly technologies to enable the integration of biochips and microfluidic systems into fully functional systems.

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Section: Delivery Systemmentioning

confidence: 99%

Device Processing Challenges for Miniaturized Sensing Systems Targeting Biological Fluids

Stoukatch

Dupont

Redouté

2022

Biomedical Materials & Devices

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“…For example, in Figure 5, in a multilayer microenvironment designed using 3DuF, the operation for loading cells requires two pathways in the multiplexers to be active while feeding two independent reservoirs simultaneously. Tools for designing valves of mVLSI devices include Biostream [113], Micado [114], and others [18,71] for placing and routing valves for a given flow layer. Next, resistive electric circuits can represent the hydraulic resistance of microfluidic networks to help optimize the number of valves in complex chips [79].…”

Section: Controlling Flow Operations In Multilayermentioning

confidence: 99%

“…For spatial-temporal mVLSI devices, algorithms have been developed to introduce computer-aided design tools for optimizing the design and control of spatially and temporally distributed microfluidic valves [ 18 , 78 ]. Following specific timings, the programmatic combination of pathways and reagents makes biological interactions rationally.…”

Section: Design Automation “Software” Workflow For Codeveloping “Hard...mentioning

confidence: 99%

“…Microfluidics are particularly interesting since they can be used to develop the design and act as an artificial environment in which highly specified biological systems can be freed from many of the highly specific environmental contexts of an actual deployment. For example, microfluidics have been used in high-throughput bioassays [ 16 ], DNA modular assembly [ 17 ], and portable devices for point-of-care applications [ 18 ].…”

Section: Introductionmentioning

confidence: 99%

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Hardware, Software, and Wetware Codesign Environment for Synthetic Biology

Oliveira

Densmore

2022

BioDesign Res

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Synthetic biology is the process of forward engineering living systems. These systems can be used to produce biobased materials, agriculture, medicine, and energy. One approach to designing these systems is to employ techniques from the design of embedded electronics. These techniques include abstraction, standards, modularity, automated design, and formal semantic models of computation. Together, these elements form the foundation of “biodesign automation,” where software, robotics, and microfluidic devices combine to create exciting biological systems of the future. This paper describes a “hardware, software, wetware” codesign vision where software tools can be made to act as “genetic compilers” that transform high-level specifications into engineered “genetic circuits” (wetware). This is followed by a process where automation equipment, well-defined experimental workflows, and microfluidic devices are explicitly designed to house, execute, and test these circuits (hardware). These systems can be used as either massively parallel experimental platforms or distributed bioremediation and biosensing devices. Next, scheduling and control algorithms (software) manage these systems’ actual execution and data analysis tasks. A distinguishing feature of this approach is how all three of these aspects (hardware, software, and wetware) may be derived from the same basic specification in parallel and generated to fulfill specific cost, performance, and structural requirements.

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“…Designing microfluidic lab-on-a-chip systems is an arduous task requiring specialized knowledge in fluid dynamics, mechanical design, and manufacturing 19 . Engineers face substantial challenges during the labor-intensive process of designing microfluidic devices.…”

Section: Introductionmentioning

confidence: 99%

Open-source interactive design platform for 3D-printed microfluidic devices

Zhang,

Li,

Tseng

et al. 2024

Commun Eng

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Microfluidics and 3D printing offer exciting opportunities for the development of new technologies and applications in the fields of biology, chemistry, and medicine. However, the design of 3D-printed microfluidic devices remains a challenging and complex task, requiring specialized knowledge and expertise in fluid mechanics, 3D modeling, and 3D printing technology. Currently, there are very few tools helping engineers to do the labor-intensive process of designing microfluidic devices, let alone any tools that can help them design microfluidic devices for 3D printing. In this work, we introduce Flui3d, an interactive software platform for designing microfluidic devices for 3D printing. Flui3d offers a standard parameterized component library, support for multi-layer design, and the ability to design and configure microfluidic devices without the need for specialized knowledge. Flui3d incorporates a distinctive Design-for-Manufacturing (DFM) function, facilitating seamless fabrication of the designed microfluidic devices using commercial consumer-grade printers. We discuss the key features and benefits of Flui3d and demonstrate them by designing examples of microfluidic devices. We also discuss the design complexity and the potential applications of Flui3d.

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Design automation for continuous-flow microfluidic biochips: A comprehensive review

Cited by 20 publications

References 96 publications

Device Processing Challenges for Miniaturized Sensing Systems Targeting Biological Fluids

Device Processing Challenges for Miniaturized Sensing Systems Targeting Biological Fluids

Hardware, Software, and Wetware Codesign Environment for Synthetic Biology

Open-source interactive design platform for 3D-printed microfluidic devices

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