Design, characterization and application of silica-bonded imidazolium-sulfonic acid chloride as a novel, active and efficient nanostructured catalyst in the synthesis of hexahydroquinolines

Experimental and theoretical studies of the nanostructured {Fe3O4@SiO2@(CH2)3Im}C(CN)3catalyst for 2-amino-3-cyanopyridine preparationviaan anomeric based oxidation

“…In the light of these facts, surveying a straightforward and newer recyclable catalytic environmentally congruous approach for the synthesis of these compounds is still a great day required and an interesting mission to the methodologists and would be valuable. In this, to conquer to the above mentioned hardships and in order to continue our work on the maturation of the design, building, applications and knowledge-based promotion of solid acids [24], inorganic acidic salts [25], nano-sphere silica with a tag of ionic liquid [26], new nanostructured ionic liquids, molten salts [27] and N-halo reagent [28] for organic functional group interconversion, we would like to inspect the application of {Fe 3 O 4 @SiO 2 @(CH 2 ) 3 Im}C(CN) 3 as a magnetically separable and reutilizable heterogeneous catalyst at the preparation of the 2-amino-3-cyanopyridines under solvent-free and mild reaction conditions as painted in Scheme 1.…”

Preparation and characterization of Cu (II) supported on poly(8‐hydroxyquinoline‐p‐styrene sulphonate) and its application as catalyst for the synthesis of hexahydroquinolines

“…Quinolines with a 1,4‐dihydropyridine structure are promising scaffolds because of their pharmacological activities. This part of quinoline derivatives has very usages in medicinal chemistry, being used as antiasthamatic, antibacterial antihypertensive, anti‐inflammatory, antimalarial, and tyrosine kinase inhibiting compounds . One of the categories of dihydropyridines (DHPs) with a modified structural scaffold is hexahydroquinolines (HHQs) which could be obtained through Hantzsch synthesis by the one‐pot four‐component condencation reaction of various aromatic aldehydes with dimedone, β ‐ketoesters and ammonium acetate in the presence of various catalysts such as silica‐bonded imidazolium‐sulfonic acid chloride, nano‐Fe 3 O 4 , 1,3‐disulfonic acid imidazolium hydrogen sulfate, nano‐Mn‐[4‐nitrophenyl‐salicylaldimine‐methyl pyranopyrazole]Cl 2 …”

Catalytic Applications of Nano‐Fe‐[Phenyl‐Salicylaldimine‐Methylpyranopyrazole]Cl2 as a Schiff Base Complex and Nanostructured Catalyst for the Synthesis of Hexahydroquinolines

“…They have been reported as antiasthmatic, antibacterial, antihypertensive, anti‐inflammatory, antimalarial, and tyrosine kinase‐inhibiting compounds . Hexahydroquinolines (HHQs) can be prepared by the condensation reaction of various aromatic aldehydes, dimedone, β‐ketoesters, and ammonium acetate via the one‐pot multicomponent condensation reaction using different catalysts . Because of the important properties of these compounds, and in continuation of our studies in the preparation of nano‐Schiff base complexes, we report here the synthesis of nano‐Fe‐[phenyl‐salicylaldimine‐methylpyranopyrazole]Cl 2 (nano‐[Fe‐PSMP]Cl 2 ) as an active complex and efficient catalyst for the preparation of hexahydroquinolines (Scheme ).…”