This is the author’s version of a work that was accepted for publication in Computer Speech and Language. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Computer Speech and Language, 28, 3 (2015) DOI: 10.1016/j.csl.2013.10.003One of the aims of Assistive Technologies is to help people with disabilities to communicate with others and to provide means of access to information. As an aid to Deaf people, we present in this work a production-quality rule-based machine system for translating from Spanish to Spanish Sign Language (LSE) glosses, which is a necessary precursor to building a full machine translation system that eventually produces animation output. The system implements a transfer-based architecture from the syntactic functions of dependency analyses. A sketch of LSE is also presented. Several topics regarding translation to sign languages are addressed: the lexical gap, the bootstrapping of a bilingual lexicon, the generation of word order for topic-oriented languages, and the treatment of classifier predicates and classifier names. The system has been evaluated with an open-domain testbed, reporting a 0.30 BLEU (BiLingual Evaluation Understudy) and 42% TER (Translation Error Rate). These results show consistent improvements over a statistical machine translation baseline, and some improvements over the same system preserving the word order in the source sentence. Finally, the linguistic analysis of errors has identified some differences due to a certain degree of structural variation in LSE