Design, economical synthesis and antiplasmodial evaluation of vanillin derived allylated chalcones and their marked synergism with artemisinin against chloroquine resistant strains of Plasmodium falciparum

Synthesis and properties of some polyethers from chalcones

“…[21] N. Sharma also synthesized and antiplasmodial evaluated the vanillin derived allylated chalcones. [22] Four hydroxy-functionalized chalcones and their characterization using various spectroscopic techniques such as LC-MS, FT-IR, FT-Raman, fluorescence spectroscopy, thermogravimetric analysis, and UV-visible absorption spectroscopy were also reported by M. Jagadeesh et al [23] The authors suggested that the hydroxy-substituted chalcones exhibited strong dual emissions as a consequence of the locally excited states followed by internal charge transfer processes.…”

Recent developments in biological activities of chalcones: A mini review

“…Recently, the synthesis and in vitro antimalarial evaluation of a series of allylated chalcones (68e70) against chloroquine (CQ) sensitive Pf3D7 and CQ-resistant PfINDO strains of Plasmodium falciparum and has been reported by Sharma et al [80] (Fig. 18).…”

Chalcone hybrids and their antimalarial activity

“…The amino tethered chalcone–quinoline hybrids 28 (Figure 6; EC 50 : 10.26–208.59 μM) showed weak to moderate activity against CQS 3D7 P. falciparum strain. [ 69–73 ] The SAR proved that the linker between chalcone and quinoline moiety was crucial for the activity, and the piperazinyl‐containing linkers were favorable to the activity. [ 74 ] Among them, hybrids 29a , b (IC 50 : 0.3–0.6 μM) were highly active against CQS D10, CQR Dd2, and W2 strains, but both of them were less potent than the reference chloroquine (IC 50 : 0.017–0.097 μM).…”