No abstract

In this paper, we present a new multilevel k-way hypergraph partitioning algorithm that substantially outperforms the existing state-of-the-art K-PMaLR algorithm for multiway partitioning, both for optimizing local as well as global objectives. Experiments on the ISPD98 benchmark suite show that the partitionings produced by our scheme are on the average 15% to 23% better than those produced by the K-PMaLR algorithm, both in terms of the hyperedge cut as well as the (K À 1) metric. Furthermore, our algorithm is signi®cantly faster, requiring 4 to 5 times less time than that required by K-PMaLR.

No abstract

The present review article describes the recent developments (2014–18) on the synthesis of ferrocene-based pharmacophores with the specific benefits of introducing/replacing organic pharmacophores with the ferrocene core for desired bioactivities.

Ferrocene is an important structural core in bioorganometallic chemistry because of its inherent stability, excellent redox properties, and low toxicity. Ferroquine and ferrocifen are two of the most notable contributions of ferrocene to medicinal chemistry with remarkable antimalarial and anticancer properties. The improved medicinal properties of these drug candidates highlight the impact that ferrocene can have on the molecular and biological properties of the bioactive compounds. In this Perspective, we investigate the scope and limitations of ferrocene incorporation into organic compounds/natural products on their mode of action and biological activities. We have also discussed the detailed role of ferrocene modifications in influencing the anticancer, antimalarial, and antimicrobial properties of various bioactive moieties to design safer and promising ferrocene-based drugs.