Design, Fabrication and Characterization of in-Plane Titanium Microneedles for Transdermal Drug Delivery

Li, Wen; Zhang, Yi Ming; Chen, Jing

doi:10.4028/www.scientific.net/kem.483.532

Cited by 5 publications

(1 citation statement)

References 6 publications

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“…75,76 Metal. Various metals, such as SS, 51,61,84,88 Ti, 81,83,120 and nickel (Ni),92 have been used as structural materials to fabricate solid MNs, coated MNs, and hollow MNs. Metals have strong mechanical strength and toughness for the transdermal drug delivery system.…”

Section: Classified By Materials Of Mnsmentioning

confidence: 99%

Microneedle System for Transdermal Drug and Vaccine Delivery: Devices, Safety, and Prospects

et al. 2019

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Microneedle (MN) delivery system has been greatly developed to deliver drugs into the skin painlessly, noninvasively, and safety. In the past several decades, various types of MNs have been developed by the newer producing techniques. Briefly, as for the morphologically, MNs can be classified into solid, coated, dissolved, and hollow MN, based on the transdermal drug delivery methods of “poke and patch,” “coat and poke,” “poke and release,” and “poke and flow,” respectively. Microneedles also have other characteristics based on the materials and structures. In addition, various manufacturing techniques have been well-developed based on the materials. In this review, the materials, structures, morphologies, and fabricating methods of MNs are summarized. A separate part of the review is used to illustrate the application of MNs to deliver vaccine, insulin, lidocaine, aspirin, and other drugs. Finally, the review ends up with a perspective on the challenges in research and development of MNs, envisioning the future development of MNs as the next generation of drug delivery system.

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Section: Classified By Materials Of Mnsmentioning

confidence: 99%

Microneedle System for Transdermal Drug and Vaccine Delivery: Devices, Safety, and Prospects

et al. 2019

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Advances in Polysaccharide-Based Microneedle Systems for the Treatment of Ocular Diseases

Bao,

Zhang,

Hao

et al. 2024

Nano-Micro Lett.

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The eye, a complex organ isolated from the systemic circulation, presents significant drug delivery challenges owing to its protective mechanisms, such as the blood-retinal barrier and corneal impermeability. Conventional drug administration methods often fail to sustain therapeutic levels and may compromise patient safety and compliance. Polysaccharide-based microneedles (PSMNs) have emerged as a transformative solution for ophthalmic drug delivery. However, a comprehensive review of PSMNs in ophthalmology has not been published to date. In this review, we critically examine the synergy between polysaccharide chemistry and microneedle technology for enhancing ocular drug delivery. We provide a thorough analysis of PSMNs, summarizing the design principles, fabrication processes, and challenges addressed during fabrication, including improving patient comfort and compliance. We also describe recent advances and the performance of various PSMNs in both research and clinical scenarios. Finally, we review the current regulatory frameworks and market barriers that are relevant to the clinical and commercial advancement of PSMNs and provide a final perspective on this research area.

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Microneedles as a potential platform for improving antibiotic delivery to bacterial infections

Abid Al-Wahaab,

Al-Mayahy

2024

Heliyon

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Design, Fabrication and Characterization of in-Plane Titanium Microneedles for Transdermal Drug Delivery

Cited by 5 publications

References 6 publications

Microneedle System for Transdermal Drug and Vaccine Delivery: Devices, Safety, and Prospects

Microneedle System for Transdermal Drug and Vaccine Delivery: Devices, Safety, and Prospects

Advances in Polysaccharide-Based Microneedle Systems for the Treatment of Ocular Diseases

Microneedles as a potential platform for improving antibiotic delivery to bacterial infections

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