Design, fabrication, and test of flexible thin-film microelectrode arrays for neural interfaces

Nahvi, Mohammad Sadegh; Boroumand, Farhad Akbari; Maghami, Mohammad Hossein; Sodagar, Amir M.; Shojaei, Amir; Mirnajafi‐Zadeh, Javad

doi:10.1109/ccece.2017.7970775

Cited by 4 publications

(4 citation statements)

References 14 publications

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“…Significant degradation of the devices was observed with stretching and time, suggesting the need for optimizing the patterning of PEDOT:PSS microstructures and to properly characterize the dependence of mechanical properties with environmental conditions. Alternative depositions, such as electro-deposition and encapsulation of the material (e.g., Parylene, Polyimide), can be explored to address these issues and to optimize the polymer deposition, as reported in several works in implantable applications [33,34,35,36].…”

Section: Discussionmentioning

confidence: 99%

Metal and Polymeric Strain Gauges for Si-Based, Monolithically Fabricated Organs-on-Chips

Quiros-Solano

Gaio

Silvestri³

et al. 2019

Micromachines

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Organ-on-chip (OOC) is becoming the alternative tool to conventional in vitro screening. Heart-on-chip devices including microstructures for mechanical and electrical stimulation have been demonstrated to be advantageous to study structural organization and maturation of heart cells. This paper presents the development of metal and polymeric strain gauges for in situ monitoring of mechanical strain in the Cytostretch platform for heart-on-chip application. Specifically, the optimization of the fabrication process of metal titanium (Ti) strain gauges and the investigation on an alternative material to improve the robustness and performance of the devices are presented. The transduction behavior and functionality of the devices are successfully proven using a custom-made set-up. The devices showed resistance changes for the pressure range (0–3 kPa) used to stretch the membranes on which heart cells can be cultured. Relative resistance changes of approximately 0.008% and 1.2% for titanium and polymeric strain gauges are respectively reported for membrane deformations up to 5%. The results demonstrate that both conventional IC metals and polymeric materials can be implemented for sensing mechanical strain using robust microfabricated organ-on-chip devices.

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Section: Discussionmentioning

confidence: 99%

Metal and Polymeric Strain Gauges for Si-Based, Monolithically Fabricated Organs-on-Chips

Quiros-Solano

Gaio

Silvestri³

et al. 2019

Micromachines

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“…As shown in the layout, vertical and horizontal pitch size of the electrodes (the ones that are actually connected) is 400 μm and 470 μm, respectively, and uniformly cover a rectangular area of 2.55 mm × 2.4 mm. Details of fabrication and characterization of the flexible MEA was published in 24 .…”

Section: Methodsmentioning

confidence: 99%

Wireless, miniaturized, semi-implantable electrocorticography microsystem validated in vivo

Keramatzadeh

Kiakojouri

Nahvi

et al. 2020

Sci Rep

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This paper reports on the design, development, and test of a multi-channel wireless micro-electrocorticography (µECoG) system. The system consists of a semi-implantable, ultra-compact recording unit and an external unit, interfaced through a 2.4 GHz radio frequency data telemetry link with 2 Mbps (partially used) data transfer rate. Encased in a 3D-printed 2.9 cm × 2.9 cm × 2.5 cm cubic package, the semi-implantable recording unit consists of a microelectrode array, a vertically-stacked PCB platform containing off-the-shelf components, and commercially-available small-size 3.7-V, 50 mAh lithium-ion batteries. Two versions of microelectrode array were developed for the recording unit: a rigid 4 × 2 microelectrode array, and a flexible 12 × 6 microelectrode array, 36 of which routed to bonding pads for actual recording. The external unit comprises a transceiver board, a data acquisition board, and a host computer, on which reconstruction of the received signals is performed. After development, assembly, and integration, the system was tested and validated in vivo on anesthetized rats. The system successfully recorded both spontaneous and evoked activities from the brain of the subject.

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“…To further decrease the mechanical mismatch between the electrodes and tissues, and achieve the so-called conformal 5 International Journal of Polymer Science electronic-tissue interface, soft substrates such as Parylene C [73], polydimethylsiloxane (PDMS) [74], SU-8 [75], polyimide (PI) [76], and silk fibroin [77] can be introduced to fabricate flexible and highly conductive neural electrodes. Compared to the metal substrate, PI, SU-8, Parylene C, and PDMS acquire much smaller Young's moduli of 8.45 GPa, 5.6 GPa, 4.0 GPa, and 1.0 MPa, respectively.…”

Section: Conducting Polymer-based Compositementioning

confidence: 99%

Conducting Polymer-Based Composite Materials for Therapeutic Implantations: From Advanced Drug Delivery System to Minimally Invasive Electronics

Liu

Yin

Chen

et al. 2020

International Journal of Polymer Science

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Conducting polymer-based composites have recently becoming popular in both academic research and industrial practices due to their high conductivity, ease of process, and tunable electrical properties. The multifunctional conducting polymer-based composites demonstrated great application potential for in vivo therapeutics and implantable electronics, including drug delivery, neural interfacing, and minimally invasive electronics. In this review article, the state-of-the-art conducting polymerbased composites in the mentioned biological fields are discussed and summarized. The recent progress on the synthesis, structure, properties, and application of the conducting polymer-based composites is presented, aimed at revealing the structure-property relationship and the corresponding functional applications of the conducting polymer-based composites. Furthermore, key issues and challenges regarding the implantation performance of these composites are highlighted in this paper.An efficient drug delivery system that can deliver the drug to targeted body sites and control the drug release rate precisely is able to improve the therapeutic outcomes and reduce the side effects [36,37]. Structuring such drug delivery systems has been long dreamed of and became more and more practical with the development of a variety of polymer-based delivery systems. From nonbiodegradable diffusion-controlled membranes [38] to biodegradable systems with a combination of diffusion and polymer matrix degradation [39], the polymer-based delivery system has shown enormous benefits in drug delivery and release. And since the 1980s, an effective and intelligent drug delivery system based on the ICPs has been developed [40,41]. Resulting from their inherent electrical, magnetic, and optical properties, the ICPs, especially their composites, are 2

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Design, fabrication, and test of flexible thin-film microelectrode arrays for neural interfaces

Cited by 4 publications

References 14 publications

Metal and Polymeric Strain Gauges for Si-Based, Monolithically Fabricated Organs-on-Chips

Metal and Polymeric Strain Gauges for Si-Based, Monolithically Fabricated Organs-on-Chips

Wireless, miniaturized, semi-implantable electrocorticography microsystem validated in vivo

Conducting Polymer-Based Composite Materials for Therapeutic Implantations: From Advanced Drug Delivery System to Minimally Invasive Electronics

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