Design in line LMA-10 Photonic Crystal Fiber MZI for Detection and investigation of Beta Thalassemia

Abstract

Consequent to the scarcity of removable rapid diagnostic examines for detecting the thalassemia, specially beta thalassemia trait or Cooly's Anemia, present detection methods include the collection of the blood, which then required being more tests before reports can be made by the treating physicians.Traditional methods like hemoglobinopathy tests and blood picture are time expending, needing specialized technical personnel, extra huge and costly laboratory instrument. Here, we simulated and demonstrated micro-hole collapsing, type of Mazh-Zehnder interferometer (MZI) that formed using LMA-!0 fiber, with a laser beam for detection the most common type of anemia, beta thalassemia trait or Cooly's Anemia .this interferometer made-up of two conventional optical fibers splicing to apart of photonic crystal fiber (PCF).this method makes a high sensitive regions for the optical characteristics in the blood sample. Biological changes in the blood sample consequent to the presence the beta thalassemia trait lead to changes optical characteristics (refractive index and absorption) of the blood sample the demonstrated laser biosensor has the ability for use as a removable, rapid diagnosis examines and the high sensitive which rises to 24.367 ABS/RIU.